decreased sensitivity to induced morbidity/mortality Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the amount of an external agent required to cause death or diseased state (Mammalian Phenotype Ontology, MP_0009764)
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75 gene mutations causing the decreased sensitivity to induced morbidity/mortality phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ACE angiotensin I converting enzyme
ADORA2B adenosine A2b receptor
AHR aryl hydrocarbon receptor
ANK1 ankyrin 1, erythrocytic
ANXA1 annexin A1
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
AQP4 aquaporin 4
BCL2A1 BCL2-related protein A1
BID BH3 interacting domain death agonist
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CASP4 caspase 4, apoptosis-related cysteine peptidase
CAT catalase
CCL13 chemokine (C-C motif) ligand 13
CCM2L cerebral cavernous malformation 2-like
CD300A CD300a molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHEK2 checkpoint kinase 2
CLEC4D C-type lectin domain family 4, member D
CLEC4E C-type lectin domain family 4, member E
CLIC4 chloride intracellular channel 4
CREB3L3 cAMP responsive element binding protein 3-like 3
CXCR2 chemokine (C-X-C motif) receptor 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
DNASE1 deoxyribonuclease I
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
EEF2 eukaryotic translation elongation factor 2
F2R coagulation factor II (thrombin) receptor
F3 coagulation factor III (thromboplastin, tissue factor)
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCMR Fc fragment of IgM receptor
GAS6 growth arrest-specific 6
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
HABP2 hyaluronan binding protein 2
IL1B interleukin 1, beta
IL33 interleukin 33
INSR insulin receptor
IP6K2 inositol hexakisphosphate kinase 2
IRAK2 interleukin-1 receptor-associated kinase 2
LTA lymphotoxin alpha
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK9 mitogen-activated protein kinase 9
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NPY1R neuropeptide Y receptor Y1
OPRM1 opioid receptor, mu 1
PDCD1 programmed cell death 1
PDE4B phosphodiesterase 4B, cAMP-specific
PELI1 pellino E3 ubiquitin protein ligase 1
PLD1 phospholipase D1, phosphatidylcholine-specific
PLG plasminogen
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RB1 retinoblastoma 1
RETNLB resistin like beta
RIPK3 receptor-interacting serine-threonine kinase 3
S1PR3 sphingosine-1-phosphate receptor 3
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SOSTDC1 sclerostin domain containing 1
SPHK1 sphingosine kinase 1
TGM2 transglutaminase 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TP53 tumor protein p53
TRIM27 tripartite motif containing 27