decreased sensitivity to induced cell death Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the exposure level to an agent that is required to induce cessation of function at the cellular level (Mammalian Phenotype Ontology, MP_0008944)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008944
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Genes

61 gene mutations causing the decreased sensitivity to induced cell death phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ANTXR1 anthrax toxin receptor 1
ANTXR2 anthrax toxin receptor 2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ATM ATM serine/threonine kinase
BBC3 BCL2 binding component 3
CASP12 caspase 12 (gene/pseudogene)
CASP9 caspase 9, apoptosis-related cysteine peptidase
CD44 CD44 molecule (Indian blood group)
CHEK2 checkpoint kinase 2
CUL9 cullin 9
CYCS cytochrome c, somatic
DAB2IP DAB2 interacting protein
DAPK1 death-associated protein kinase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DPH1 diphthamide biosynthesis 1
DUSP6 dual specificity phosphatase 6
EEF2 eukaryotic translation elongation factor 2
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ERCC2 excision repair cross-complementation group 2
ERO1L ERO1-like (S. cerevisiae)
FAF1 Fas (TNFRSF6) associated factor 1
GPX1 glutathione peroxidase 1
HELLS helicase, lymphoid-specific
HINT1 histidine triad nucleotide binding protein 1
HIPK1 homeodomain interacting protein kinase 1
HIPK2 homeodomain interacting protein kinase 2
HIST1H1C histone cluster 1, H1c
IFT122 intraflagellar transport 122
JUN jun proto-oncogene
MAP2K6 mitogen-activated protein kinase kinase 6
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MBD4 methyl-CpG binding domain protein 4
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MLH1 mutL homolog 1
MLKL mixed lineage kinase domain-like
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
NBN nibrin
NDRG1 N-myc downstream regulated 1
NIT1 nitrilase 1
NOA1 nitric oxide associated 1
OMA1 OMA1 zinc metallopeptidase
PER2 period circadian clock 2
PERP PERP, TP53 apoptosis effector
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPIF peptidylprolyl isomerase F
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAD51D RAD51 paralog D
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RIPK3 receptor-interacting serine-threonine kinase 3
SETD7 SET domain containing (lysine methyltransferase) 7
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SPP1 secreted phosphoprotein 1
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TP53 tumor protein p53
TP63 tumor protein p63
TRIM27 tripartite motif containing 27
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
XPA xeroderma pigmentosum, complementation group A