decreased pro-b cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs (Mammalian Phenotype Ontology, MP_0008208)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008208
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Genes

39 gene mutations causing the decreased pro-b cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ATP11C ATPase, class VI, type 11C
BAD BCL2-associated agonist of cell death
CCR9 chemokine (C-C motif) receptor 9
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
EBF1 early B-cell factor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FLT3 fms-related tyrosine kinase 3
FLT3LG fms-related tyrosine kinase 3 ligand
FZD9 frizzled class receptor 9
GON4L gon-4-like (C. elegans)
HAX1 HCLS1 associated protein X-1
HTRA2 HtrA serine peptidase 2
IFNB1 interferon, beta 1, fibroblast
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL6 interleukin 6
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
KAT6A K(lysine) acetyltransferase 6A
KMT2E lysine (K)-specific methyltransferase 2E
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
NLK nemo-like kinase
PAX5 paired box 5
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
RAD50 RAD50 homolog (S. cerevisiae)
RAG1 recombination activating gene 1
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SH3BP2 SH3-domain binding protein 2
SOX4 SRY (sex determining region Y)-box 4
SPI1 Spi-1 proto-oncogene
TCF12 transcription factor 12
TCF3 transcription factor 3
TCF4 transcription factor 4
TET2 tet methylcytosine dioxygenase 2
TWSG1 twisted gastrulation BMP signaling modulator 1
ZBTB7A zinc finger and BTB domain containing 7A