decreased primordial germ cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge (Mammalian Phenotype Ontology, MP_0008392)
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22 gene mutations causing the decreased primordial germ cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BCL2L1 BCL2-like 1
BMP4 bone morphogenetic protein 4
BMP8B bone morphogenetic protein 8b
CTDNEP1 CTD nuclear envelope phosphatase 1
CXCR4 chemokine (C-X-C motif) receptor 4
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
FANCL Fanconi anemia, complementation group L
KITLG KIT ligand
LARP7 La ribonucleoprotein domain family, member 7
LIN28A lin-28 homolog A (C. elegans)
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)
MCM9 minichromosome maintenance complex component 9
NANOS3 nanos homolog 3 (Drosophila)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PRDM1 PR domain containing 1, with ZNF domain
REST RE1-silencing transcription factor
ROR2 receptor tyrosine kinase-like orphan receptor 2
SMAD1 SMAD family member 1
SMAD5 SMAD family member 5
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
WNT5A wingless-type MMTV integration site family, member 5A
ZFX zinc finger protein, X-linked