decreased prepulse inhibition Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus (Mammalian Phenotype Ontology, MP_0009142)
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69 gene mutations causing the decreased prepulse inhibition phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AFM afamin
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ATF7 activating transcription factor 7
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
AVPR1A arginine vasopressin receptor 1A
CCK cholecystokinin
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CIB2 calcium and integrin binding family member 2
CTNNA2 catenin (cadherin-associated protein), alpha 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSC cathepsin C
DGCR8 DGCR8 microprocessor complex subunit
DISC1 disrupted in schizophrenia 1
DVL1 dishevelled segment polarity protein 1
ELMOD1 ELMO/CED-12 domain containing 1
FABP7 fatty acid binding protein 7, brain
FAM134C family with sequence similarity 134, member C
FBXO11 F-box protein 11
FXR2 fragile X mental retardation, autosomal homolog 2
FZD3 frizzled class receptor 3
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRM8 glutamate receptor, metabotropic 8
GSK3B glycogen synthase kinase 3 beta
HMGN1 high mobility group nucleosome binding domain 1
HMGN3 high mobility group nucleosomal binding domain 3
HMGN5 high mobility group nucleosome binding domain 5
KALRN kalirin, RhoGEF kinase
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
LPAR1 lysophosphatidic acid receptor 1
LRRC7 leucine rich repeat containing 7
MAT2A methionine adenosyltransferase II, alpha
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MECP2 methyl CpG binding protein 2
MIB2 mindbomb E3 ubiquitin protein ligase 2
NPC1 Niemann-Pick disease, type C1
NPTN neuroplastin
NRCAM neuronal cell adhesion molecule
NRXN1 neurexin 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POMK protein-O-mannose kinase
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PREP prolyl endopeptidase
PTEN phosphatase and tensin homolog
S1PR4 sphingosine-1-phosphate receptor 4
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1
SNAP25 synaptosomal-associated protein, 25kDa
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
SRR serine racemase
SYNGAP1 synaptic Ras GTPase activating protein 1
TBX1 T-box 1
TIMP2 TIMP metallopeptidase inhibitor 2
TMOD2 tropomodulin 2 (neuronal)
TRIB2 tribbles pseudokinase 2
TYROBP TYRO protein tyrosine kinase binding protein
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
ZDHHC17 zinc finger, DHHC-type containing 17
ZDHHC8 zinc finger, DHHC-type containing 8
ZIC2 Zic family member 2