decreased platelet serotonin level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced amount in platelets of serotonin, a biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity (Mammalian Phenotype Ontology, MP_0004725)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004725
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Genes

15 gene mutations causing the decreased platelet serotonin level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AP3B1 adaptor-related protein complex 3, beta 1 subunit
AP3D1 adaptor-related protein complex 3, delta 1 subunit
BLOC1S4 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino
BLOC1S5 biogenesis of lysosomal organelles complex-1, subunit 5, muted
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
DTNBP1 dystrobrevin binding protein 1
HPS1 Hermansky-Pudlak syndrome 1
HPS3 Hermansky-Pudlak syndrome 3
HPS4 Hermansky-Pudlak syndrome 4
HPS5 Hermansky-Pudlak syndrome 5
LYST lysosomal trafficking regulator
RAB27A RAB27A, member RAS oncogene family
RAB27B RAB27B, member RAS oncogene family
SLC35D3 solute carrier family 35, member D3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11