decreased pancreatic alpha cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the number of the cells of the pancreas that secrete glucagon (Mammalian Phenotype Ontology, MP_0009177)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009177
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Genes

16 gene mutations causing the decreased pancreatic alpha cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AQP7 aquaporin 7
ARX aristaless related homeobox
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
DACH1 dachshund family transcription factor 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
GLIS3 GLIS family zinc finger 3
INS insulin
INSM1 insulinoma-associated 1
ISL1 ISL LIM homeobox 1
NEUROD1 neuronal differentiation 1
NEUROG3 neurogenin 3
NKX2-2 NK2 homeobox 2
ONECUT1 one cut homeobox 1
PAX6 paired box 6
PTF1A pancreas specific transcription factor, 1a
SEC23B Sec23 homolog B (S. cerevisiae)