decreased osteoclast cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced number of the specialized phagocytic cells associated with the absorption and removal of the mineralized matrix of bone tissue (Mammalian Phenotype Ontology, MP_0004985)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004985
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Genes

42 gene mutations causing the decreased osteoclast cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AGER advanced glycosylation end product-specific receptor
ANKRD11 ankyrin repeat domain 11
C3 complement component 3
C3AR1 complement component 3a receptor 1
C5AR1 complement component 5a receptor 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCR2 chemokine (C-C motif) receptor 2
CD47 CD47 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
COL10A1 collagen, type X, alpha 1
CSF1 colony stimulating factor 1 (macrophage)
CTSV cathepsin V
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
ESRRA estrogen-related receptor alpha
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FOS FBJ murine osteosarcoma viral oncogene homolog
GAB2 GRB2-associated binding protein 2
GPR55 G protein-coupled receptor 55
HCST hematopoietic cell signal transducer
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
KL klotho
LRP5 low density lipoprotein receptor-related protein 5
MC4R melanocortin 4 receptor
MITF microphthalmia-associated transcription factor
MMP2 matrix metallopeptidase 2
MSX2 msh homeobox 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS2 nitric oxide synthase 2, inducible
NPY2R neuropeptide Y receptor Y2
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PTH parathyroid hormone
PTHLH parathyroid hormone-like hormone
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RGS10 regulator of G-protein signaling 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
SUCO SUN domain containing ossification factor
THRA thyroid hormone receptor, alpha
TMEM64 transmembrane protein 64
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11