decreased osteoblast cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the number of skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell (Mammalian Phenotype Ontology, MP_0004989)
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31 gene mutations causing the decreased osteoblast cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADIPOQ adiponectin, C1Q and collagen domain containing
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)
ATF4 activating transcription factor 4
BGN biglycan
CRH corticotropin releasing hormone
CTHRC1 collagen triple helix repeat containing 1
ESR1 estrogen receptor 1
FBLIM1 filamin binding LIM protein 1
FGFR2 fibroblast growth factor receptor 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FZD9 frizzled class receptor 9
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
IGF2 insulin-like growth factor 2
IHH indian hedgehog
IL6ST interleukin 6 signal transducer
IRS1 insulin receptor substrate 1
ITGB1BP1 integrin beta 1 binding protein 1
JAM2 junctional adhesion molecule 2
KL klotho
LRP5 low density lipoprotein receptor-related protein 5
MIA3 melanoma inhibitory activity family, member 3
MMP2 matrix metallopeptidase 2
NPY4R neuropeptide Y receptor Y4
PTH parathyroid hormone
PTHLH parathyroid hormone-like hormone
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RUNX2 runt-related transcription factor 2
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TGFB1 transforming growth factor, beta 1