decreased neuron apoptosis Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description decrease in the number of neurons undergoing programmed cell death (Mammalian Phenotype Ontology, MP_0003204)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003204
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Genes

66 gene mutations causing the decreased neuron apoptosis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
APAF1 apoptotic peptidase activating factor 1
BAG6 BCL2-associated athanogene 6
BAX BCL2-associated X protein
CASP12 caspase 12 (gene/pseudogene)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCL13 chemokine (C-C motif) ligand 13
DAPK1 death-associated protein kinase 1
DDIT3 DNA-damage-inducible transcript 3
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
EGLN3 egl-9 family hypoxia-inducible factor 3
FAF1 Fas (TNFRSF6) associated factor 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FGF8 fibroblast growth factor 8 (androgen-induced)
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRM2 glutamate receptor, metabotropic 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIPK2 homeodomain interacting protein kinase 2
HIST1H2BJ histone cluster 1, H2bj
HRK harakiri, BCL2 interacting protein
JUN jun proto-oncogene
MAGED1 melanoma antigen family D1
MAOB monoamine oxidase B
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAPK10 mitogen-activated protein kinase 10
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPT microtubule-associated protein tau
MMP9 matrix metallopeptidase 9
MUTYH mutY homolog
NGFR nerve growth factor receptor
NOS1 nitric oxide synthase 1 (neuronal)
NOX4 NADPH oxidase 4
NTF4 neurotrophin 4
PANX1 pannexin 1
PARP1 poly (ADP-ribose) polymerase 1
PERP PERP, TP53 apoptosis effector
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLG plasminogen
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RASD1 RAS, dexamethasone-induced 1
RET ret proto-oncogene
SARM1 sterile alpha and TIR motif containing 1
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCG synuclein, gamma (breast cancer-specific protein 1)
SPP1 secreted phosphoprotein 1
SRR serine racemase
STAT1 signal transducer and activator of transcription 1, 91kDa
STIM2 stromal interaction molecule 2
SURF1 surfeit 1
TGFB3 transforming growth factor, beta 3
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TP53 tumor protein p53
TRPC5 transient receptor potential cation channel, subfamily C, member 5
UBE2K ubiquitin-conjugating enzyme E2K
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UNC5A unc-5 homolog A (C. elegans)