decreased motor neuron number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses (Mammalian Phenotype Ontology, MP_0000939)
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43 gene mutations causing the decreased motor neuron number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AFG3L2 AFG3-like AAA ATPase 2
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
CLCF1 cardiotrophin-like cytokine factor 1
CLP1 cleavage and polyadenylation factor I subunit 1
CNTF ciliary neurotrophic factor
CNTFR ciliary neurotrophic factor receptor
CP ceruloplasmin (ferroxidase)
CRLF1 cytokine receptor-like factor 1
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EGR3 early growth response 3
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans)
ETV4 ets variant 4
GBX1 gastrulation brain homeobox 1
GDF15 growth differentiation factor 15
GDNF glial cell derived neurotrophic factor
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GFRA1 GDNF family receptor alpha 1
GPHN gephyrin
HHAT hedgehog acyltransferase
HOXC10 homeobox C10
IGF1 insulin-like growth factor 1 (somatomedin C)
KIDINS220 kinase D-interacting substrate, 220kDa
KIF5C kinesin family member 5C
KISS1R KISS1 receptor
LEPR leptin receptor
LIF leukemia inhibitory factor
LIFR leukemia inhibitory factor receptor alpha
LMX1B LIM homeobox transcription factor 1, beta
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
NEFM neurofilament, medium polypeptide
NGFR nerve growth factor receptor
NKX6-1 NK6 homeobox 1
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NRG1 neuregulin 1
NTF3 neurotrophin 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLIG2 oligodendrocyte lineage transcription factor 2
PHOX2A paired-like homeobox 2a
RET ret proto-oncogene
RND3 Rho family GTPase 3
SCYL1 SCY1-like 1 (S. cerevisiae)
SHH sonic hedgehog
SMN1 survival of motor neuron 1, telomeric