decreased megakaryocyte cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm (Mammalian Phenotype Ontology, MP_0008255)
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15 gene mutations causing the decreased megakaryocyte cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CBFB core-binding factor, beta subunit
CDK6 cyclin-dependent kinase 6
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOXP3 forkhead box P3
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL6ST interleukin 6 signal transducer
JAK1 Janus kinase 1
MED1 mediator complex subunit 1
MEIS1 Meis homeobox 1
MPL MPL proto-oncogene, thrombopoietin receptor
OSMR oncostatin M receptor
THPO thrombopoietin
TTC7A tetratricopeptide repeat domain 7A
ZFPM1 zinc finger protein, FOG family member 1