decreased mean corpuscular volume Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices (Mammalian Phenotype Ontology, MP_0002591)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002591
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Genes

60 gene mutations causing the decreased mean corpuscular volume phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADD1 adducin 1 (alpha)
ADD2 adducin 2 (beta)
ADGRF5 adhesion G protein-coupled receptor F5
AHSP alpha hemoglobin stabilizing protein
ANK1 ankyrin 1, erythrocytic
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
ARID4A AT rich interactive domain 4A (RBP1-like)
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
COL4A5 collagen, type IV, alpha 5
DBN1 drebrin 1
DMTN dematin actin binding protein
EHD1 EH-domain containing 1
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
EPB41 erythrocyte membrane protein band 4.1
EPB42 erythrocyte membrane protein band 4.2
EXOC6 exocyst complex component 6
FAM132B family with sequence similarity 132, member B
FAM63A family with sequence similarity 63, member A
FGG fibrinogen gamma chain
GLG1 golgi glycoprotein 1
GRHL3 grainyhead-like 3 (Drosophila)
GTPBP2 GTP binding protein 2
HBA1 hemoglobin, alpha 1
HEPH hephaestin
HMGB3 high mobility group box 3
HMOX1 heme oxygenase 1
IREB2 iron-responsive element binding protein 2
JAK1 Janus kinase 1
JAK2 Janus kinase 2
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNIP4 Kv channel interacting protein 4
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
MAP2K7 mitogen-activated protein kinase kinase 7
MIR144 microRNA 144
MIR451A microRNA 451a
NCKAP1L NCK-associated protein 1-like
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae)
NSUN2 NOP2/Sun RNA methyltransferase family, member 2
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R15B protein phosphatase 1, regulatory subunit 15B
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
RAB5C RAB5C, member RAS oncogene family
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RNF10 ring finger protein 10
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SPTA1 spectrin, alpha, erythrocytic 1
SRSF4 serine/arginine-rich splicing factor 4
STEAP3 STEAP family member 3, metalloreductase
TAL1 T-cell acute lymphocytic leukemia 1
TF transferrin
TFRC transferrin receptor
TMPRSS6 transmembrane protease, serine 6
TTC7A tetratricopeptide repeat domain 7A
USP21 ubiquitin specific peptidase 21
USP24 ubiquitin specific peptidase 24