decreased marginal zone b cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL (Mammalian Phenotype Ontology, MP_0008182)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008182
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Genes

52 gene mutations causing the decreased marginal zone b cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACKR3 atypical chemokine receptor 3
APOE apolipoprotein E
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARID3A AT rich interactive domain 3A (BRIGHT-like)
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCL10 B-cell CLL/lymphoma 10
BLNK B-cell linker
CD22 CD22 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CDH17 cadherin 17, LI cadherin (liver-intestine)
DOCK2 dedicator of cytokinesis 2
DOCK8 dedicator of cytokinesis 8
DTX1 deltex 1, E3 ubiquitin ligase
FAS Fas cell surface death receptor
FCMR Fc fragment of IgM receptor
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
HAX1 HCLS1 associated protein X-1
IGHM immunoglobulin heavy constant mu
IKZF3 IKAROS family zinc finger 3 (Aiolos)
LTA lymphotoxin alpha
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAML1 mastermind-like 1 (Drosophila)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NKX2-3 NK2 homeobox 3
NOTCH2 notch 2
NPY1R neuropeptide Y receptor Y1
PARP14 poly (ADP-ribose) polymerase family, member 14
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PNP purine nucleoside phosphorylase
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SASH3 SAM and SH3 domain containing 3
SFN stratifin
SH2D3C SH2 domain containing 3C
SIAE sialic acid acetylesterase
SPPL2A signal peptide peptidase like 2A
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STK4 serine/threonine kinase 4
SYK spleen tyrosine kinase
TLR8 toll-like receptor 8
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
UNC93B1 unc-93 homolog B1 (C. elegans)
WAS Wiskott-Aldrich syndrome
ZEB1 zinc finger E-box binding homeobox 1