decreased macrophage cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description fewer than the normal numbers of macrophages (Mammalian Phenotype Ontology, MP_0003884)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003884
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Genes

78 gene mutations causing the decreased macrophage cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADGRE1 adhesion G protein-coupled receptor E1
AGER advanced glycosylation end product-specific receptor
ANKRD11 ankyrin repeat domain 11
APC adenomatous polyposis coli
ARHGAP15 Rho GTPase activating protein 15
BCL3 B-cell CLL/lymphoma 3
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
C3 complement component 3
C3AR1 complement component 3a receptor 1
C5AR1 complement component 5a receptor 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCBE1 collagen and calcium binding EGF domains 1
CCL13 chemokine (C-C motif) ligand 13
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CD47 CD47 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
COL10A1 collagen, type X, alpha 1
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CTSV cathepsin V
CXCL14 chemokine (C-X-C motif) ligand 14
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
ESRRA estrogen-related receptor alpha
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FLT3LG fms-related tyrosine kinase 3 ligand
FOS FBJ murine osteosarcoma viral oncogene homolog
GAB2 GRB2-associated binding protein 2
GJD4 gap junction protein, delta 4, 40.1kDa
GPR55 G protein-coupled receptor 55
GPR68 G protein-coupled receptor 68
HCST hematopoietic cell signal transducer
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
IFNB1 interferon, beta 1, fibroblast
IL13 interleukin 13
IL1RL2 interleukin 1 receptor-like 2
IRF8 interferon regulatory factor 8
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KL klotho
KMT2E lysine (K)-specific methyltransferase 2E
LGALS3 lectin, galactoside-binding, soluble, 3
LRP5 low density lipoprotein receptor-related protein 5
LYST lysosomal trafficking regulator
MAEA macrophage erythroblast attacher
MC4R melanocortin 4 receptor
MDK midkine (neurite growth-promoting factor 2)
MFAP2 microfibrillar-associated protein 2
MINA MYC induced nuclear antigen
MITF microphthalmia-associated transcription factor
MMP2 matrix metallopeptidase 2
MSI2 musashi RNA-binding protein 2
MSX2 msh homeobox 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS2 nitric oxide synthase 2, inducible
NPY2R neuropeptide Y receptor Y2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTH parathyroid hormone
PTHLH parathyroid hormone-like hormone
PTN pleiotrophin
RAD50 RAD50 homolog (S. cerevisiae)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RGS10 regulator of G-protein signaling 10
SHCBP1 SHC SH2-domain binding protein 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPI1 Spi-1 proto-oncogene
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
SUCO SUN domain containing ossification factor
THRA thyroid hormone receptor, alpha
TMEM64 transmembrane protein 64
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TRIB1 tribbles pseudokinase 1