decreased litter size Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description fewer live born pups in a litter compared to average (Mammalian Phenotype Ontology, MP_0001935)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001935
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Genes

260 gene mutations causing the decreased litter size phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACADL acyl-CoA dehydrogenase, long chain
ACE angiotensin I converting enzyme
ACSL4 acyl-CoA synthetase long-chain family member 4
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADCY3 adenylate cyclase 3
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADRA1B adrenoceptor alpha 1B
AGTPBP1 ATP/GTP binding protein 1
AHR aryl hydrocarbon receptor
AKAP1 A kinase (PRKA) anchor protein 1
AKR1C3 aldo-keto reductase family 1, member C3
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ALKBH5 AlkB family member 5, RNA demethylase
ALPPL2 alkaline phosphatase, placental-like 2
AMBP alpha-1-microglobulin/bikunin precursor
APLNR apelin receptor
AR androgen receptor
ARID4A AT rich interactive domain 4A (RBP1-like)
ARSB arylsulfatase B
ASPH aspartate beta-hydroxylase
ASTL astacin-like metallo-endopeptidase (M12 family)
ATAT1 alpha tubulin acetyltransferase 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP7A ATPase, Cu++ transporting, alpha polypeptide
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3
ATXN2 ataxin 2
AURKC aurora kinase C
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCL2L1 BCL2-like 1
BMP15 bone morphogenetic protein 15
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CABLES1 Cdk5 and Abl enzyme substrate 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CBS cystathionine-beta-synthase
CCNB2 cyclin B2
CCS copper chaperone for superoxide dismutase
CD320 CD320 molecule
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDC14B cell division cycle 14B
CDH23 cadherin-related 23
CELF1 CUGBP, Elav-like family member 1
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CHST10 carbohydrate sulfotransferase 10
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLIC4 chloride intracellular channel 4
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
COL1A1 collagen, type I, alpha 1
CSF1 colony stimulating factor 1 (macrophage)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL4A cullin 4A
CXCL14 chemokine (C-X-C motif) ligand 14
DLK1 delta-like 1 homolog (Drosophila)
DLL3 delta-like 3 (Drosophila)
DMD dystrophin
DNAH11 dynein, axonemal, heavy chain 11
DSE dermatan sulfate epimerase
EDARADD EDAR-associated death domain
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF4H eukaryotic translation initiation factor 4H
EPHA4 EPH receptor A4
ESR2 estrogen receptor 2 (ER beta)
ETNK2 ethanolamine kinase 2
F10 coagulation factor X
FAM212A family with sequence similarity 212, member A
FANCA Fanconi anemia, complementation group A
FANCC Fanconi anemia, complementation group C
FKBP4 FK506 binding protein 4, 59kDa
FOXN1 forkhead box N1
FREM2 FRAS1 related extracellular matrix protein 2
FSHR follicle stimulating hormone receptor
FST follistatin
FUS FUS RNA binding protein
FZD1 frizzled class receptor 1
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GBA2 glucosidase, beta (bile acid) 2
GCGR glucagon receptor
GDF5 growth differentiation factor 5
GHR growth hormone receptor
GHRH growth hormone releasing hormone
GJA1 gap junction protein, alpha 1, 43kDa
GMCL1 germ cell-less, spermatogenesis associated 1
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPR3 G protein-coupled receptor 3
GPRC6A G protein-coupled receptor, class C, group 6, member A
GRHL2 grainyhead-like 2 (Drosophila)
GSTA4 glutathione S-transferase alpha 4
HBZ hemoglobin, zeta
HELQ helicase, POLQ-like
HEXA hexosaminidase A (alpha polypeptide)
HOOK1 hook microtubule-tethering protein 1
HOXA10 homeobox A10
HOXA11 homeobox A11
HSF2 heat shock transcription factor 2
IFNG interferon, gamma
IGF2R insulin-like growth factor 2 receptor
IGFALS insulin-like growth factor binding protein, acid labile subunit
IL11RA interleukin 11 receptor, alpha
INSL5 insulin-like 5
INSL6 insulin-like 6
IRS4 insulin receptor substrate 4
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KHDC3L KH domain containing 3-like, subcortical maternal complex member
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KPNA1 karyopherin alpha 1 (importin alpha 5)
LAMP2 lysosomal-associated membrane protein 2
LBH limb bud and heart development
LIN28A lin-28 homolog A (C. elegans)
LIPC lipase, hepatic
LPAR3 lysophosphatidic acid receptor 3
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
MAGEL2 melanoma antigen family L2
MAK male germ cell-associated kinase
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MARK2 MAP/microtubule affinity-regulating kinase 2
MBD2 methyl-CpG binding domain protein 2
MDC1 mediator of DNA-damage checkpoint 1
MEP1A meprin A, alpha (PABA peptide hydrolase)
MEP1B meprin A, beta
MFGE8 milk fat globule-EGF factor 8 protein
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase
MITF microphthalmia-associated transcription factor
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MOS v-mos Moloney murine sarcoma viral oncogene homolog
MPP1 membrane protein, palmitoylated 1, 55kDa
MRC1 mannose receptor, C type 1
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOA2 nuclear receptor coactivator 2
NCOA3 nuclear receptor coactivator 3
NCOA6 nuclear receptor coactivator 6
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NHLH2 nescient helix loop helix 2
NKD1 naked cuticle homolog 1 (Drosophila)
NKD2 naked cuticle homolog 2 (Drosophila)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPEPPS aminopeptidase puromycin sensitive
NPM2 nucleophosmin/nucleoplasmin 2
NPR2 natriuretic peptide receptor 2
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRG2 neuregulin 2
NSUN7 NOP2/Sun domain family, member 7
NXF2 nuclear RNA export factor 2
OCA2 oculocutaneous albinism II
OPRM1 opioid receptor, mu 1
OTX2 orthodenticle homeobox 2
OXTR oxytocin receptor
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PA2G4 proliferation-associated 2G4, 38kDa
PAH phenylalanine hydroxylase
PANK2 pantothenate kinase 2
PARP1 poly (ADP-ribose) polymerase 1
PCSK4 proprotein convertase subtilisin/kexin type 4
PDE4D phosphodiesterase 4D, cAMP-specific
PER1 period circadian clock 1
PER2 period circadian clock 2
PEX7 peroxisomal biogenesis factor 7
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLA2G3 phospholipase A2, group III
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAG1 pleiomorphic adenoma gene 1
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
PPP5C protein phosphatase 5, catalytic subunit
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRS protein tyrosine phosphatase, receptor type, S
PTTG1 pituitary tumor-transforming 1
PTX3 pentraxin 3, long
RAD21L1 RAD21-like 1 (S. pombe)
RAD23B RAD23 homolog B (S. cerevisiae)
RAD51C RAD51 paralog C
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RAP1B RAP1B, member of RAS oncogene family
RNF141 ring finger protein 141
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
ROPN1 rhophilin associated tail protein 1
S1PR2 sphingosine-1-phosphate receptor 2
S1PR3 sphingosine-1-phosphate receptor 3
SAFB scaffold attachment factor B
SEPP1 selenoprotein P, plasma, 1
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SFRP4 secreted frizzled-related protein 4
SHH sonic hedgehog
SLC13A1 solute carrier family 13 (sodium/sulfate symporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLX4 SLX4 structure-specific endonuclease subunit
SMAD5 SMAD family member 5
SMAD7 SMAD family member 7
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
SNAI2 snail family zinc finger 2
SOD1 superoxide dismutase 1, soluble
SOX8 SRY (sex determining region Y)-box 8
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRED2 sprouty-related, EVH1 domain containing 2
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STRBP spermatid perinuclear RNA binding protein
STX2 syntaxin 2
SULF2 sulfatase 2
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
SYCP2 synaptonemal complex protein 2
SYCP3 synaptonemal complex protein 3
T T, brachyury homolog (mouse)
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
TCL1A T-cell leukemia/lymphoma 1A
TEKT4 tektin 4
TERC telomerase RNA component
TERT telomerase reverse transcriptase
TET1 tet methylcytosine dioxygenase 1
THBS1 thrombospondin 1
THRA thyroid hormone receptor, alpha
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNP1 transition protein 1 (during histone to protamine replacement)
TNP2 transition protein 2 (during histone to protamine replacement)
TNS1 tensin 1
TOP3B topoisomerase (DNA) III beta
TP53BP1 tumor protein p53 binding protein 1
TPST1 tyrosylprotein sulfotransferase 1
TRAF4 TNF receptor-associated factor 4
TRIM28 tripartite motif containing 28
TRIM32 tripartite motif containing 32
TSIX TSIX transcript, XIST antisense RNA
TSN translin
TTLL5 tubulin tyrosine ligase-like family member 5
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1
UBE3A ubiquitin protein ligase E3A
USP2 ubiquitin specific peptidase 2
VEGFA vascular endothelial growth factor A
WIPF3 WAS/WASL interacting protein family, member 3
WNT6 wingless-type MMTV integration site family, member 6
WWTR1 WW domain containing transcription regulator 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP42 ZFP42 zinc finger protein
ZP1 zona pellucida glycoprotein 1 (sperm receptor)