decreased leukotriene level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced concentration of a family of mediators derived from arachidonic acid which normally stimulate smooth muscle contraction, increase vascular permeability, and may be chemoattractants for inflammatory cells (Mammalian Phenotype Ontology, MP_0009817)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009817
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Genes

4 gene mutations causing the decreased leukotriene level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ORAI1 ORAI calcium release-activated calcium modulator 1
PTGES prostaglandin E synthase