decreased lean body mass Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced amount of the fat-free physical bulk or volume of the body including all its components except adipose (fat) tissue (Mammalian Phenotype Ontology, MP_0003961)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003961
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Genes

121 gene mutations causing the decreased lean body mass phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
ACOT11 acyl-CoA thioesterase 11
ACSL3 acyl-CoA synthetase long-chain family member 3
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADIPOR2 adiponectin receptor 2
AGRP agouti related neuropeptide
AHCYL1 adenosylhomocysteinase-like 1
AKAP9 A kinase (PRKA) anchor protein 9
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ARL4D ADP-ribosylation factor-like 4D
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
B9D1 B9 protein domain 1
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BBS5 Bardet-Biedl syndrome 5
BBX bobby sox homolog (Drosophila)
BRPF1 bromodomain and PHD finger containing, 1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CBX6 chromobox homolog 6
CENPJ centromere protein J
CHD7 chromodomain helicase DNA binding protein 7
CISD2 CDGSH iron sulfur domain 2
CLSTN3 calsyntenin 3
CNIH1 cornichon family AMPA receptor auxiliary protein 1
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung)
CRH corticotropin releasing hormone
CRLF3 cytokine receptor-like factor 3
CSRP2BP CSRP2 binding protein
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
CUL7 cullin 7
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DAAM2 dishevelled associated activator of morphogenesis 2
DEGS1 delta(4)-desaturase, sphingolipid 1
DLL1 delta-like 1 (Drosophila)
DMXL2 Dmx-like 2
DNASE1L2 deoxyribonuclease I-like 2
DUSP3 dual specificity phosphatase 3
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ELMOD1 ELMO/CED-12 domain containing 1
FAM73B family with sequence similarity 73, member B
FARSA phenylalanyl-tRNA synthetase, alpha subunit
FBXO11 F-box protein 11
FOXP2 forkhead box P2
FTO fat mass and obesity associated
GDF15 growth differentiation factor 15
GHR growth hormone receptor
GHRHR growth hormone releasing hormone receptor
GLP1R glucagon-like peptide 1 receptor
GNAS GNAS complex locus
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPR39 G protein-coupled receptor 39
GPRC6A G protein-coupled receptor, class C, group 6, member A
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LPIN1 lipin 1
MC3R melanocortin 3 receptor
MECOM MDS1 and EVI1 complex locus
MFSD2A major facilitator superfamily domain containing 2A
MRAP2 melanocortin 2 receptor accessory protein 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MXRA7 matrix-remodelling associated 7
MYO7A myosin VIIA
MYSM1 Myb-like, SWIRM and MPN domains 1
NEGR1 neuronal growth regulator 1
NMUR2 neuromedin U receptor 2
NPTN neuroplastin
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NSUN2 NOP2/Sun RNA methyltransferase family, member 2
NXN nucleoredoxin
OSTM1 osteopetrosis associated transmembrane protein 1
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6
PACS2 phosphofurin acidic cluster sorting protein 2
PDE10A phosphodiesterase 10A
PDYN prodynorphin
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PYY peptide YY
RBMX RNA binding motif protein, X-linked
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
SCP2 sterol carrier protein 2
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SELK selenoprotein K
SERINC1 serine incorporator 1
SFRP1 secreted frizzled-related protein 1
SFRP2 secreted frizzled-related protein 2
SFRP5 secreted frizzled-related protein 5
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
SLC38A10 solute carrier family 38, member 10
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19
SMS spermine synthase
SNAP47 synaptosomal-associated protein, 47kDa
SNIP1 Smad nuclear interacting protein 1
SPP1 secreted phosphoprotein 1
SPPL3 signal peptide peptidase like 3
STRA6 stimulated by retinoic acid 6
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SYT1 synaptotagmin I
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TCF4 transcription factor 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TMEM189 transmembrane protein 189
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNIK TRAF2 and NCK interacting kinase
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TSN translin
TTLL1 tubulin tyrosine ligase-like family member 1
TTLL4 tubulin tyrosine ligase-like family member 4
UBE3B ubiquitin protein ligase E3B
USP24 ubiquitin specific peptidase 24
USP38 ubiquitin specific peptidase 38
ZC3HC1 zinc finger, C3HC-type containing 1