decreased interleukin-6 secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts (Mammalian Phenotype Ontology, MP_0008706)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008706
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Genes

75 gene mutations causing the decreased interleukin-6 secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
APOE apolipoprotein E
AZI2 5-azacytidine induced 2
CARD9 caspase recruitment domain family, member 9
CC2D1A coiled-coil and C2 domain containing 1A
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD200R1 CD200 receptor 1
CD36 CD36 molecule (thrombospondin receptor)
CLEC4E C-type lectin domain family 4, member E
CLEC6A C-type lectin domain family 6, member A
CLIC4 chloride intracellular channel 4
CNPY3 canopy FGF signaling regulator 3
CORO1A coronin, actin binding protein, 1A
CXCL6 chemokine (C-X-C motif) ligand 6
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
F3 coagulation factor III (thromboplastin, tissue factor)
FASTK Fas-activated serine/threonine kinase
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCMR Fc fragment of IgM receptor
GADD45B growth arrest and DNA-damage-inducible, beta
IDO2 indoleamine 2,3-dioxygenase 2
IFIH1 interferon induced with helicase C domain 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL17RB interleukin 17 receptor B
IL1R1 interleukin 1 receptor, type I
IL1RAP interleukin 1 receptor accessory protein
IL33 interleukin 33
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK4 interleukin-1 receptor-associated kinase 4
IRF5 interferon regulatory factor 5
LGMN legumain
LY96 lymphocyte antigen 96
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAVS mitochondrial antiviral signaling protein
MYD88 myeloid differentiation primary response 88
NAMPT nicotinamide phosphoribosyltransferase
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
NLRC5 NLR family, CARD domain containing 5
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
PBK PDZ binding kinase
PELI1 pellino E3 ubiquitin protein ligase 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G2D phospholipase A2, group IID
RIPK2 receptor-interacting serine-threonine kinase 2
SELK selenoprotein K
SH2D3C SH2 domain containing 3C
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4
SMAD3 SMAD family member 3
SQSTM1 sequestosome 1
STIM1 stromal interaction molecule 1
TICAM1 toll-like receptor adaptor molecule 1
TICAM2 toll-like receptor adaptor molecule 2
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TLR6 toll-like receptor 6
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TOLLIP toll interacting protein
TRADD TNFRSF1A-associated via death domain
TRAF3IP2 TRAF3 interacting protein 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
UNC93B1 unc-93 homolog B1 (C. elegans)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor