decreased interleukin-4 secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells (Mammalian Phenotype Ontology, MP_0008700)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008700
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Genes

60 gene mutations causing the decreased interleukin-4 secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
B2M beta-2-microglobulin
BATF basic leucine zipper transcription factor, ATF-like
C3AR1 complement component 3a receptor 1
CADM1 cell adhesion molecule 1
CCL13 chemokine (C-C motif) ligand 13
CCR4 chemokine (C-C motif) receptor 4
CCR6 chemokine (C-C motif) receptor 6
CCRL2 chemokine (C-C motif) receptor-like 2
CD1D CD1d molecule
CD28 CD28 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC10A C-type lectin domain family 10, member A
CLNK cytokine-dependent hematopoietic cell linker
CXCL16 chemokine (C-X-C motif) ligand 16
EBI3 Epstein-Barr virus induced 3
FPR2 formyl peptide receptor 2
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
ICOS inducible T-cell co-stimulator
ICOSLG inducible T-cell co-stimulator ligand
IL13 interleukin 13
IL13RA2 interleukin 13 receptor, alpha 2
IL1B interleukin 1, beta
IL1RL1 interleukin 1 receptor-like 1
IL20RB interleukin 20 receptor beta
IL21R interleukin 21 receptor
IL25 interleukin 25
IL2RG interleukin 2 receptor, gamma
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6ST interleukin 6 signal transducer
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MIR155 microRNA 155
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
ORAI1 ORAI calcium release-activated calcium modulator 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCQ protein kinase C, theta
RAD50 RAD50 homolog (S. cerevisiae)
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RFTN1 raftlin, lipid raft linker 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RSAD2 radical S-adenosyl methionine domain containing 2
SASH3 SAM and SH3 domain containing 3
SLAMF6 SLAM family member 6
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
VAV1 vav 1 guanine nucleotide exchange factor
VIPR2 vasoactive intestinal peptide receptor 2
VTCN1 V-set domain containing T cell activation inhibitor 1