decreased interleukin-21 secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the production or release of a pleiotropic cytokine that regulates immunoglobulin production, plasma cell and Th17 T cell differentiation, CD8+ T cell expansion, and inhibits antigen presentation by dendritic cells (Mammalian Phenotype Ontology, MP_0009058)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009058
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Genes

5 gene mutations causing the decreased interleukin-21 secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BATF basic leucine zipper transcription factor, ATF-like
CD84 CD84 molecule
ICOS inducible T-cell co-stimulator
IL21R interleukin 21 receptor
SH2D1A SH2 domain containing 1A