decreased interleukin-2 secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes (Mammalian Phenotype Ontology, MP_0008688)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008688
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Genes

56 gene mutations causing the decreased interleukin-2 secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AHNAK AHNAK nucleoprotein
AIRE autoimmune regulator
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
BCL2L1 BCL2-like 1
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BTLA B and T lymphocyte associated
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CADM1 cell adhesion molecule 1
CARD11 caspase recruitment domain family, member 11
CCL5 chemokine (C-C motif) ligand 5
CCR2 chemokine (C-C motif) receptor 2
CD1D CD1d molecule
CD28 CD28 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CORO1A coronin, actin binding protein, 1A
DBNL drebrin-like
FAS Fas cell surface death receptor
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FPR2 formyl peptide receptor 2
FYB FYN binding protein
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45B growth arrest and DNA-damage-inducible, beta
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HRH1 histamine receptor H1
IL1B interleukin 1, beta
IL2RG interleukin 2 receptor, gamma
ITK IL2-inducible T-cell kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
MALT1 MALT1 paracaspase
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NME2 NME/NM23 nucleoside diphosphate kinase 2
ORAI1 ORAI calcium release-activated calcium modulator 1
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
POU2AF1 POU class 2 associating factor 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCQ protein kinase C, theta
PRKD2 protein kinase D2
RAP1A RAP1A, member of RAS oncogene family
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2
RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
SASH3 SAM and SH3 domain containing 3
SH2D2A SH2 domain containing 2A
SKAP1 src kinase associated phosphoprotein 1
TESPA1 thymocyte expressed, positive selection associated 1
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
VAV1 vav 1 guanine nucleotide exchange factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa