decreased interferon-gamma secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation (Mammalian Phenotype Ontology, MP_0008567)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008567
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Genes

132 gene mutations causing the decreased interferon-gamma secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AHNAK AHNAK nucleoprotein
AIM2 absent in melanoma 2
APOE apolipoprotein E
BCL3 B-cell CLL/lymphoma 3
BHLHE41 basic helix-loop-helix family, member e41
BTLA B and T lymphocyte associated
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CADM1 cell adhesion molecule 1
CARD11 caspase recruitment domain family, member 11
CCL13 chemokine (C-C motif) ligand 13
CCL5 chemokine (C-C motif) ligand 5
CCR2 chemokine (C-C motif) receptor 2
CD1D CD1d molecule
CD28 CD28 molecule
CD69 CD69 molecule
CD7 CD7 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CLEC4F C-type lectin domain family 4, member F
CLEC6A C-type lectin domain family 6, member A
CRTAM cytotoxic and regulatory T cell molecule
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL16 chemokine (C-X-C motif) ligand 16
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
DUSP4 dual specificity phosphatase 4
ERAP1 endoplasmic reticulum aminopeptidase 1
FADS1 fatty acid desaturase 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FLT3 fms-related tyrosine kinase 3
FOXN1 forkhead box N1
FPR2 formyl peptide receptor 2
FYN FYN proto-oncogene, Src family tyrosine kinase
G6PC2 glucose-6-phosphatase, catalytic, 2
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
HAVCR2 hepatitis A virus cellular receptor 2
HCST hematopoietic cell signal transducer
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-G major histocompatibility complex, class I, G
HRH1 histamine receptor H1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
ICOS inducible T-cell co-stimulator
IDO2 indoleamine 2,3-dioxygenase 2
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNG interferon, gamma
IL12B interleukin 12B
IL12RB1 interleukin 12 receptor, beta 1
IL13 interleukin 13
IL15 interleukin 15
IL17A interleukin 17A
IL17C interleukin 17C
IL18 interleukin 18
IL18R1 interleukin 18 receptor 1
IL1B interleukin 1, beta
IL21R interleukin 21 receptor
IL23A interleukin 23, alpha subunit p19
IL27RA interleukin 27 receptor, alpha
IL2RG interleukin 2 receptor, gamma
IL34 interleukin 34
IL4 interleukin 4
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
IRF1 interferon regulatory factor 1
IRF8 interferon regulatory factor 8
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITK IL2-inducible T-cell kinase
JAK3 Janus kinase 3
LAT linker for activation of T cells
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LIG4 ligase IV, DNA, ATP-dependent
LTA lymphotoxin alpha
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAPK14 mitogen-activated protein kinase 14
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MIR155 microRNA 155
MMP9 matrix metallopeptidase 9
MYD88 myeloid differentiation primary response 88
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NFIL3 nuclear factor, interleukin 3 regulated
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NLRP10 NLR family, pyrin domain containing 10
NME2 NME/NM23 nucleoside diphosphate kinase 2
NPY1R neuropeptide Y receptor Y1
ORAI1 ORAI calcium release-activated calcium modulator 1
PIGR polymeric immunoglobulin receptor
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POU2AF1 POU class 2 associating factor 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRF1 perforin 1 (pore forming protein)
PRKCQ protein kinase C, theta
PRKD2 protein kinase D2
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PYCARD PYD and CARD domain containing
RCAN1 regulator of calcineurin 1
RETNLB resistin like beta
RFTN1 raftlin, lipid raft linker 1
RIPK2 receptor-interacting serine-threonine kinase 2
RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
RNF19B ring finger protein 19B
SASH3 SAM and SH3 domain containing 3
SH2D1A SH2 domain containing 1A
SH2D1B SH2 domain containing 1B
SH2D2A SH2 domain containing 2A
SKAP1 src kinase associated phosphoprotein 1
SPP1 secreted phosphoprotein 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT4 signal transducer and activator of transcription 4
TBX21 T-box 21
TESPA1 thymocyte expressed, positive selection associated 1
THBS1 thrombospondin 1
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TYK2 tyrosine kinase 2
TYROBP TYRO protein tyrosine kinase binding protein
USP18 ubiquitin specific peptidase 18
USP25 ubiquitin specific peptidase 25
VAV1 vav 1 guanine nucleotide exchange factor
XCR1 chemokine (C motif) receptor 1