decreased insulin secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the production or release of the hormone secreted by beta cells of the pancreas that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids (Mammalian Phenotype Ontology, MP_0003059)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003059
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Genes

83 gene mutations causing the decreased insulin secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACE angiotensin I converting enzyme
ADIPOQ adiponectin, C1Q and collagen domain containing
AKAP5 A kinase (PRKA) anchor protein 5
ALX3 ALX homeobox 3
ANXA7 annexin A7
ARNTL aryl hydrocarbon receptor nuclear translocator-like
BAD BCL2-associated agonist of cell death
BGLAP bone gamma-carboxyglutamate (gla) protein
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CADPS2 Ca++-dependent secretion activator 2
CARTPT CART prepropeptide
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CHGB chromogranin B
CHRM3 cholinergic receptor, muscarinic 3
CISD2 CDGSH iron sulfur domain 2
CLOCK clock circadian regulator
COL5A3 collagen, type V, alpha 3
CYB5R4 cytochrome b5 reductase 4
E2F1 E2F transcription factor 1
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ERO1LB ERO1-like beta (S. cerevisiae)
ESR2 estrogen receptor 2 (ER beta)
FAM3B family with sequence similarity 3, member B
FEM1B fem-1 homolog b (C. elegans)
FFAR1 free fatty acid receptor 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXA1 forkhead box A1
GAL galanin/GMAP prepropeptide
GCK glucokinase (hexokinase 4)
GEM GTP binding protein overexpressed in skeletal muscle
GJD2 gap junction protein, delta 2, 36kDa
GLIS3 GLIS family zinc finger 3
GLUD1 glutamate dehydrogenase 1
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPER1 G protein-coupled estrogen receptor 1
GPR68 G protein-coupled receptor 68
HIPK3 homeodomain interacting protein kinase 3
HMGA1 high mobility group AT-hook 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
IL6 interleukin 6
INS insulin
IRS1 insulin receptor substrate 1
KL klotho
KMT2B lysine (K)-specific methyltransferase 2B
LEP leptin
LEPR leptin receptor
LPIN1 lipin 1
LRP5 low density lipoprotein receptor-related protein 5
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
MAPK8 mitogen-activated protein kinase 8
NAMPT nicotinamide phosphoribosyltransferase
NKX2-2 NK2 homeobox 2
NKX6-1 NK6 homeobox 1
NNT nicotinamide nucleotide transhydrogenase
PASK PAS domain containing serine/threonine kinase
PBX1 pre-B-cell leukemia homeobox 1
PCSK2 proprotein convertase subtilisin/kexin type 2
PDX1 pancreatic and duodenal homeobox 1
PFKM phosphofructokinase, muscle
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCD protein kinase C, delta
PRLR prolactin receptor
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RIMS2 regulating synaptic membrane exocytosis 2
RNF213 ring finger protein 213
RPH3AL rabphilin 3A-like (without C2 domains)
RPS6 ribosomal protein S6
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SAMD4A sterile alpha motif domain containing 4A
SERTAD1 SERTA domain containing 1
SGMS1 sphingomyelin synthase 1
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
SNAP25 synaptosomal-associated protein, 25kDa
SOX4 SRY (sex determining region Y)-box 4
STXBP3 syntaxin binding protein 3
SYTL1 synaptotagmin-like 1
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TRH thyrotropin-releasing hormone
UCN3 urocortin 3
UNC13A unc-13 homolog A (C. elegans)