decreased inflammatory response Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormal reduction in the inflammatory response to injury or infection. (Human Phenotype Ontology, HP_0012648)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001876
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Genes

218 gene mutations causing the decreased inflammatory response phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACOT11 acyl-CoA thioesterase 11
ADORA3 adenosine A3 receptor
AHR aryl hydrocarbon receptor
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA5 annexin A5
AOC3 amine oxidase, copper containing 3
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
APCS amyloid P component, serum
APOE apolipoprotein E
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BBS12 Bardet-Biedl syndrome 12
BCL2A1 BCL2-related protein A1
BDKRB1 bradykinin receptor B1
BID BH3 interacting domain death agonist
BIRC3 baculoviral IAP repeat containing 3
BTK Bruton agammaglobulinemia tyrosine kinase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCKBR cholecystokinin B receptor
CCL13 chemokine (C-C motif) ligand 13
CCL17 chemokine (C-C motif) ligand 17
CCL3L3 chemokine (C-C motif) ligand 3-like 3
CCL5 chemokine (C-C motif) ligand 5
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CCRL2 chemokine (C-C motif) receptor-like 2
CD14 CD14 molecule
CD1D CD1d molecule
CD207 CD207 molecule, langerin
CD28 CD28 molecule
CD33 CD33 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD81 CD81 molecule
CD83 CD83 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CERS6 ceramide synthase 6
CLEC4D C-type lectin domain family 4, member D
CLEC4E C-type lectin domain family 4, member E
CLIC4 chloride intracellular channel 4
CPA3 carboxypeptidase A3 (mast cell)
CREB3L3 cAMP responsive element binding protein 3-like 3
CRH corticotropin releasing hormone
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL9 chemokine (C-X-C motif) ligand 9
CYSLTR1 cysteinyl leukotriene receptor 1
CYSLTR2 cysteinyl leukotriene receptor 2
ECM1 extracellular matrix protein 1
EDNRB endothelin receptor type B
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHB6 EPH receptor B6
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FPR2 formyl peptide receptor 2
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GAB2 GRB2-associated binding protein 2
GCA grancalcin, EF-hand calcium binding protein
GGT5 gamma-glutamyltransferase 5
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GSN gelsolin
HLA-DMA major histocompatibility complex, class II, DM alpha
HRH1 histamine receptor H1
HRH4 histamine receptor H4
ICAM1 intercellular adhesion molecule 1
ICOSLG inducible T-cell co-stimulator ligand
IDO1 indoleamine 2,3-dioxygenase 1
IDO2 indoleamine 2,3-dioxygenase 2
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGHM immunoglobulin heavy constant mu
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL12A interleukin 12A
IL12B interleukin 12B
IL13 interleukin 13
IL13RA2 interleukin 13 receptor, alpha 2
IL15 interleukin 15
IL17A interleukin 17A
IL17F interleukin 17F
IL17RA interleukin 17 receptor A
IL17RB interleukin 17 receptor B
IL17RC interleukin 17 receptor C
IL18 interleukin 18
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL21R interleukin 21 receptor
IL3 interleukin 3
IL33 interleukin 33
IL34 interleukin 34
IL4 interleukin 4
IL6 interleukin 6
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK4 interleukin-1 receptor-associated kinase 4
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KIF1C kinesin family member 1C
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LBP lipopolysaccharide binding protein
LITAF lipopolysaccharide-induced TNF factor
LTA lymphotoxin alpha
LTA4H leukotriene A4 hydrolase
LTB4R leukotriene B4 receptor
LTB4R2 leukotriene B4 receptor 2
LTC4S leukotriene C4 synthase
LY96 lymphocyte antigen 96
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MEP1B meprin A, beta
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MINA MYC induced nuclear antigen
MMP1 matrix metallopeptidase 1
MMP19 matrix metallopeptidase 19
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MYD88 myeloid differentiation primary response 88
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NLRP10 NLR family, pyrin domain containing 10
NLRP12 NLR family, pyrin domain containing 12
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NPY1R neuropeptide Y receptor Y1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR2C2 nuclear receptor subfamily 2, group C, member 2
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
ORAI1 ORAI calcium release-activated calcium modulator 1
PARP1 poly (ADP-ribose) polymerase 1
PELI1 pellino E3 ubiquitin protein ligase 1
PGF placental growth factor
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLA2G10 phospholipase A2, group X
PLA2G3 phospholipase A2, group III
PLA2G5 phospholipase A2, group V
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRKCG protein kinase C, gamma
PTAFR platelet-activating factor receptor
PTGDR prostaglandin D2 receptor (DP)
PTGDR2 prostaglandin D2 receptor 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGES prostaglandin E synthase
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2B protein tyrosine kinase 2 beta
PTPRC protein tyrosine phosphatase, receptor type, C
PYCARD PYD and CARD domain containing
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RETNLB resistin like beta
RHOH ras homolog family member H
RIPK3 receptor-interacting serine-threonine kinase 3
S100A9 S100 calcium binding protein A9
S1PR3 sphingosine-1-phosphate receptor 3
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SPHK1 sphingosine kinase 1
SPP1 secreted phosphoprotein 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STIM1 stromal interaction molecule 1
STX2 syntaxin 2
STXBP2 syntaxin binding protein 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACR1 tachykinin receptor 1
TBXAS1 thromboxane A synthase 1 (platelet)
TERF2IP telomeric repeat binding factor 2, interacting protein
TGM2 transglutaminase 2
TICAM1 toll-like receptor adaptor molecule 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRADD TNFRSF1A-associated via death domain
TRAF3IP2 TRAF3 interacting protein 2
TRIP10 thyroid hormone receptor interactor 10
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSLP thymic stromal lymphopoietin
TYROBP TYRO protein tyrosine kinase binding protein
UBE2N ubiquitin-conjugating enzyme E2N
VIPR2 vasoactive intestinal peptide receptor 2