decreased immature b cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity (Mammalian Phenotype Ontology, MP_0008215)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008215
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Genes

75 gene mutations causing the decreased immature b cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AKAP13 A kinase (PRKA) anchor protein 13
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATM ATM serine/threonine kinase
ATP11C ATPase, class VI, type 11C
BCL2 B-cell CLL/lymphoma 2
BCL3 B-cell CLL/lymphoma 3
BIRC3 baculoviral IAP repeat containing 3
BLNK B-cell linker
BST1 bone marrow stromal cell antigen 1
BTK Bruton agammaglobulinemia tyrosine kinase
CARD11 caspase recruitment domain family, member 11
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CD22 CD22 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
COMMD3-BMI1 COMMD3-BMI1 readthrough
CREBBP CREB binding protein
CXCR4 chemokine (C-X-C motif) receptor 4
CYCS cytochrome c, somatic
CYLD cylindromatosis (turban tumor syndrome)
DCLRE1C DNA cross-link repair 1C
DLK1 delta-like 1 homolog (Drosophila)
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
EWSR1 EWS RNA-binding protein 1
FAS Fas cell surface death receptor
FNIP1 folliculin interacting protein 1
GON4L gon-4-like (C. elegans)
HAX1 HCLS1 associated protein X-1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL2RG interleukin 2 receptor, gamma
IL7R interleukin 7 receptor
JAK3 Janus kinase 3
KAT6A K(lysine) acetyltransferase 6A
LTA lymphotoxin alpha
LYN LYN proto-oncogene, Src family tyrosine kinase
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MSI2 musashi RNA-binding protein 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTSS1 metastasis suppressor 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPY1R neuropeptide Y receptor Y1
PAX5 paired box 5
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POU2AF1 POU class 2 associating factor 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RAD50 RAD50 homolog (S. cerevisiae)
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SH2D1A SH2 domain containing 1A
SH3BP2 SH3-domain binding protein 2
SOX4 SRY (sex determining region Y)-box 4
SPNS2 spinster homolog 2 (Drosophila)
SPPL2A signal peptide peptidase like 2A
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SYK spleen tyrosine kinase
TCF12 transcription factor 12
TCF3 transcription factor 3
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TRAF2 TNF receptor-associated factor 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TWSG1 twisted gastrulation BMP signaling modulator 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZBTB1 zinc finger and BTB domain containing 1