decreased igm level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormally decreased level of immunoglobulin IgM in blood. (Human Phenotype Ontology, HP_0002850)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001806
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Genes

92 gene mutations causing the decreased igm level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ATP11C ATPase, class VI, type 11C
BATF basic leucine zipper transcription factor, ATF-like
BCL10 B-cell CLL/lymphoma 10
BCL6 B-cell CLL/lymphoma 6
BLM Bloom syndrome, RecQ helicase-like
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
C1QBP complement component 1, q subcomponent binding protein
CARD11 caspase recruitment domain family, member 11
CD19 CD19 molecule
CD22 CD22 molecule
CD28 CD28 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD79A CD79a molecule, immunoglobulin-associated alpha
CD83 CD83 molecule
COMMD3-BMI1 COMMD3-BMI1 readthrough
CR2 complement component (3d/Epstein Barr virus) receptor 2
CTSS cathepsin S
CYLD cylindromatosis (turban tumor syndrome)
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DBNL drebrin-like
DOCK8 dedicator of cytokinesis 8
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EBF1 early B-cell factor 1
FCMR Fc fragment of IgM receptor
FNIP1 folliculin interacting protein 1
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
HDAC6 histone deacetylase 6
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXC4 homeobox C4
HR hair growth associated
HRH1 histamine receptor H1
ICOSLG inducible T-cell co-stimulator ligand
IFNG interferon, gamma
IGHM immunoglobulin heavy constant mu
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL15 interleukin 15
IL17A interleukin 17A
IL2RG interleukin 2 receptor, gamma
IL4 interleukin 4
IL5RA interleukin 5 receptor, alpha
IRF4 interferon regulatory factor 4
JCHAIN joining chain of multimeric IgA and IgM
LIG4 ligase IV, DNA, ATP-dependent
MALT1 MALT1 paracaspase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MARK2 MAP/microtubule affinity-regulating kinase 2
MIR155 microRNA 155
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NIPAL3 NIPA-like domain containing 3
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PITX3 paired-like homeodomain 3
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POLQ polymerase (DNA directed), theta
POU2F2 POU class 2 homeobox 2
PRKCB protein kinase C, beta
PRKD2 protein kinase D2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTTG1 pituitary tumor-transforming 1
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RUVBL2 RuvB-like AAA ATPase 2
SASH3 SAM and SH3 domain containing 3
SFN stratifin
SH2D1A SH2 domain containing 1A
SH2D3C SH2 domain containing 3C
SH3BP2 SH3-domain binding protein 2
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SKAP2 src kinase associated phosphoprotein 2
SPPL2A signal peptide peptidase like 2A
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TLR7 toll-like receptor 7
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TRAF5 TNF receptor-associated factor 5
VAV2 vav 2 guanine nucleotide exchange factor
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZEB1 zinc finger E-box binding homeobox 1