decreased igg2a level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description less than normal immunoglobulin class G2a level (Mammalian Phenotype Ontology, MP_0008496)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008496
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Genes

74 gene mutations causing the decreased igg2a level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AICDA activation-induced cytidine deaminase
ATF3 activating transcription factor 3
ATM ATM serine/threonine kinase
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
CARD11 caspase recruitment domain family, member 11
CD180 CD180 molecule
CD19 CD19 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD40 CD40 molecule, TNF receptor superfamily member 5
CD83 CD83 molecule
CR2 complement component (3d/Epstein Barr virus) receptor 2
CXCL10 chemokine (C-X-C motif) ligand 10
DHRS4 dehydrogenase/reductase (SDR family) member 4
DUSP4 dual specificity phosphatase 4
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FNIP1 folliculin interacting protein 1
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
HAX1 HCLS1 associated protein X-1
HOXC4 homeobox C4
ICOS inducible T-cell co-stimulator
ICOSLG inducible T-cell co-stimulator ligand
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IGHM immunoglobulin heavy constant mu
IL17A interleukin 17A
IL21R interleukin 21 receptor
IL23A interleukin 23, alpha subunit p19
IL25 interleukin 25
IL6ST interleukin 6 signal transducer
IRF2 interferon regulatory factor 2
ITFG2 integrin alpha FG-GAP repeat containing 2
ITPKB inositol-trisphosphate 3-kinase B
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAVS mitochondrial antiviral signaling protein
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NPY1R neuropeptide Y receptor Y1
PDCD1LG2 programmed cell death 1 ligand 2
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
POU2AF1 POU class 2 associating factor 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PVR poliovirus receptor
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RCAN1 regulator of calcineurin 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RETNLB resistin like beta
RFTN1 raftlin, lipid raft linker 1
RIPK2 receptor-interacting serine-threonine kinase 2
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
SASH3 SAM and SH3 domain containing 3
SH2D1A SH2 domain containing 1A
SIGLEC10 sialic acid binding Ig-like lectin 10
SKAP2 src kinase associated phosphoprotein 2
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPPL2A signal peptide peptidase like 2A
SYK spleen tyrosine kinase
TICAM1 toll-like receptor adaptor molecule 1
TLR7 toll-like receptor 7
TNF tumor necrosis factor
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TYK2 tyrosine kinase 2
VAV1 vav 1 guanine nucleotide exchange factor