decreased igg1 level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description less than normal immunoglobulin class G1 level (Mammalian Phenotype Ontology, MP_0008495)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008495
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Genes

116 gene mutations causing the decreased igg1 level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AICDA activation-induced cytidine deaminase
AKAP13 A kinase (PRKA) anchor protein 13
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATP11C ATPase, class VI, type 11C
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BATF basic leucine zipper transcription factor, ATF-like
BCL6 B-cell CLL/lymphoma 6
BIRC3 baculoviral IAP repeat containing 3
C3AR1 complement component 3a receptor 1
CARD11 caspase recruitment domain family, member 11
CD19 CD19 molecule
CD22 CD22 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD37 CD37 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CD81 CD81 molecule
CD83 CD83 molecule
CHD7 chromodomain helicase DNA binding protein 7
CLUAP1 clusterin associated protein 1
CR2 complement component (3d/Epstein Barr virus) receptor 2
DBNL drebrin-like
DLL1 delta-like 1 (Drosophila)
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FCMR Fc fragment of IgM receptor
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FNIP1 folliculin interacting protein 1
FPR2 formyl peptide receptor 2
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXC4 homeobox C4
HRH4 histamine receptor H4
ICOS inducible T-cell co-stimulator
ICOSLG inducible T-cell co-stimulator ligand
IFNAR2 interferon (alpha, beta and omega) receptor 2
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHM immunoglobulin heavy constant mu
IGLL1 immunoglobulin lambda-like polypeptide 1
IL13 interleukin 13
IL17A interleukin 17A
IL21 interleukin 21
IL21R interleukin 21 receptor
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5RA interleukin 5 receptor, alpha
IL6ST interleukin 6 signal transducer
IRF4 interferon regulatory factor 4
ITFG2 integrin alpha FG-GAP repeat containing 2
ITPKB inositol-trisphosphate 3-kinase B
KDM8 lysine (K)-specific demethylase 8
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAVS mitochondrial antiviral signaling protein
MIR155 microRNA 155
MSH2 mutS homolog 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NHEJ1 nonhomologous end-joining factor 1
NLRP10 NLR family, pyrin domain containing 10
NUP98 nucleoporin 98kDa
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
POLQ polymerase (DNA directed), theta
POU2AF1 POU class 2 associating factor 1
POU2F2 POU class 2 homeobox 2
PRKD2 protein kinase D2
PRMT8 protein arginine methyltransferase 8
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PVR poliovirus receptor
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RIF1 replication timing regulatory factor 1
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RSAD2 radical S-adenosyl methionine domain containing 2
RUVBL2 RuvB-like AAA ATPase 2
SASH3 SAM and SH3 domain containing 3
SDC1 syndecan 1
SH2D1A SH2 domain containing 1A
SH2D3C SH2 domain containing 3C
SH3BP2 SH3-domain binding protein 2
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPNS2 spinster homolog 2 (Drosophila)
SPPL2A signal peptide peptidase like 2A
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SYK spleen tyrosine kinase
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TNF tumor necrosis factor
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRAF5 TNF receptor-associated factor 5
TYK2 tyrosine kinase 2
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
ZEB1 zinc finger E-box binding homeobox 1