decreased igg level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormally decreased level of immunoglobulin IgG in blood. (Human Phenotype Ontology, HP_0004315)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001805
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Genes

208 gene mutations causing the decreased igg level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AICDA activation-induced cytidine deaminase
AKAP13 A kinase (PRKA) anchor protein 13
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATF3 activating transcription factor 3
ATM ATM serine/threonine kinase
ATP11C ATPase, class VI, type 11C
AVPR1A arginine vasopressin receptor 1A
B2M beta-2-microglobulin
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BATF basic leucine zipper transcription factor, ATF-like
BCL10 B-cell CLL/lymphoma 10
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BIRC3 baculoviral IAP repeat containing 3
BLNK B-cell linker
BST1 bone marrow stromal cell antigen 1
BTK Bruton agammaglobulinemia tyrosine kinase
C3AR1 complement component 3a receptor 1
CARD11 caspase recruitment domain family, member 11
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CD180 CD180 molecule
CD19 CD19 molecule
CD1D CD1d molecule
CD22 CD22 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD37 CD37 molecule
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CD81 CD81 molecule
CD83 CD83 molecule
CD84 CD84 molecule
CD86 CD86 molecule
CDH17 cadherin 17, LI cadherin (liver-intestine)
CHD7 chromodomain helicase DNA binding protein 7
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CIITA class II, major histocompatibility complex, transactivator
CLEC4D C-type lectin domain family 4, member D
CLEC4E C-type lectin domain family 4, member E
CLUAP1 clusterin associated protein 1
CR2 complement component (3d/Epstein Barr virus) receptor 2
CTSS cathepsin S
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYLD cylindromatosis (turban tumor syndrome)
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DBNL drebrin-like
DHRS4 dehydrogenase/reductase (SDR family) member 4
DLL1 delta-like 1 (Drosophila)
DOCK2 dedicator of cytokinesis 2
DOCK8 dedicator of cytokinesis 8
DUSP4 dual specificity phosphatase 4
FAS Fas cell surface death receptor
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FCMR Fc fragment of IgM receptor
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FNIP1 folliculin interacting protein 1
FPR2 formyl peptide receptor 2
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
H2AFX H2A histone family, member X
HAX1 HCLS1 associated protein X-1
HDAC6 histone deacetylase 6
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXC4 homeobox C4
HRH1 histamine receptor H1
HRH4 histamine receptor H4
ICOS inducible T-cell co-stimulator
ICOSLG inducible T-cell co-stimulator ligand
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IGHD immunoglobulin heavy constant delta
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHM immunoglobulin heavy constant mu
IGLL1 immunoglobulin lambda-like polypeptide 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL13 interleukin 13
IL15 interleukin 15
IL17A interleukin 17A
IL21 interleukin 21
IL21R interleukin 21 receptor
IL23A interleukin 23, alpha subunit p19
IL25 interleukin 25
IL2RG interleukin 2 receptor, gamma
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5RA interleukin 5 receptor, alpha
IL6ST interleukin 6 signal transducer
IRF1 interferon regulatory factor 1
IRF2 interferon regulatory factor 2
IRF4 interferon regulatory factor 4
ITFG2 integrin alpha FG-GAP repeat containing 2
ITPKB inositol-trisphosphate 3-kinase B
JAK3 Janus kinase 3
JCHAIN joining chain of multimeric IgA and IgM
KDM8 lysine (K)-specific demethylase 8
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LIG4 ligase IV, DNA, ATP-dependent
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LY86 lymphocyte antigen 86
MALT1 MALT1 paracaspase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MARK2 MAP/microtubule affinity-regulating kinase 2
MAVS mitochondrial antiviral signaling protein
MIR155 microRNA 155
MSH2 mutS homolog 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYD88 myeloid differentiation primary response 88
MYO6 myosin VI
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NHEJ1 nonhomologous end-joining factor 1
NLRP10 NLR family, pyrin domain containing 10
NOD2 nucleotide-binding oligomerization domain containing 2
NPY1R neuropeptide Y receptor Y1
NUP98 nucleoporin 98kDa
PDCD1LG2 programmed cell death 1 ligand 2
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PITX3 paired-like homeodomain 3
POLQ polymerase (DNA directed), theta
POMT1 protein-O-mannosyltransferase 1
POU2AF1 POU class 2 associating factor 1
POU2F2 POU class 2 homeobox 2
PRKCB protein kinase C, beta
PRKD2 protein kinase D2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRMT8 protein arginine methyltransferase 8
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTTG1 pituitary tumor-transforming 1
PVR poliovirus receptor
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RCAN1 regulator of calcineurin 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RETNLB resistin like beta
RFTN1 raftlin, lipid raft linker 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RIF1 replication timing regulatory factor 1
RIPK2 receptor-interacting serine-threonine kinase 2
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RSAD2 radical S-adenosyl methionine domain containing 2
RUVBL2 RuvB-like AAA ATPase 2
SASH3 SAM and SH3 domain containing 3
SDC1 syndecan 1
SFN stratifin
SH2D1A SH2 domain containing 1A
SH2D3C SH2 domain containing 3C
SH3BP2 SH3-domain binding protein 2
SHARPIN SHANK-associated RH domain interactor
SIGLEC10 sialic acid binding Ig-like lectin 10
SKAP2 src kinase associated phosphoprotein 2
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPNS2 spinster homolog 2 (Drosophila)
SPPL2A signal peptide peptidase like 2A
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SYK spleen tyrosine kinase
SYTL1 synaptotagmin-like 1
TICAM1 toll-like receptor adaptor molecule 1
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TNF tumor necrosis factor
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRADD TNFRSF1A-associated via death domain
TRAF5 TNF receptor-associated factor 5
TRIP10 thyroid hormone receptor interactor 10
TYK2 tyrosine kinase 2
UNG uracil-DNA glycosylase
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZEB1 zinc finger E-box binding homeobox 1