decreased hemoglobin content Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description decrease in the total hemoglobin content in the circulating blood (Mammalian Phenotype Ontology, MP_0002874)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002874
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Genes

126 gene mutations causing the decreased hemoglobin content phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ADD2 adducin 2 (beta)
ADGRF5 adhesion G protein-coupled receptor F5
ANK1 ankyrin 1, erythrocytic
ARCN1 archain 1
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARID4A AT rich interactive domain 4A (RBP1-like)
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
CD47 CD47 molecule
CD59 CD59 molecule, complement regulatory protein
CIAPIN1 cytokine induced apoptosis inhibitor 1
CLEC1B C-type lectin domain family 1, member B
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A5 collagen, type IV, alpha 5
DBN1 drebrin 1
DKC1 dyskeratosis congenita 1, dyskerin
ELMOD1 ELMO/CED-12 domain containing 1
EPB42 erythrocyte membrane protein band 4.2
ERCC2 excision repair cross-complementation group 2
EXOC6 exocyst complex component 6
FAM132B family with sequence similarity 132, member B
FAM134C family with sequence similarity 134, member C
FAM83G family with sequence similarity 83, member G
FBXO7 F-box protein 7
FECH ferrochelatase
FGFRL1 fibroblast growth factor receptor-like 1
FOXP3 forkhead box P3
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAS GNAS complex locus
HBA1 hemoglobin, alpha 1
HEPH hephaestin
HK1 hexokinase 1
HMOX1 heme oxygenase 1
HOXB4 homeobox B4
HYAL2 hyaluronoglucosaminidase 2
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10 interleukin 10
IL10RB interleukin 10 receptor, beta
IREB2 iron-responsive element binding protein 2
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JMJD6 jumonji domain containing 6
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KDM4C lysine (K)-specific demethylase 4C
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KLF1 Kruppel-like factor 1 (erythroid)
KLF3 Kruppel-like factor 3 (basic)
KMT2A lysine (K)-specific methyltransferase 2A
KMT2E lysine (K)-specific methyltransferase 2E
LAMA4 laminin, alpha 4
LDHA lactate dehydrogenase A
LGMN legumain
LMO2 LIM domain only 2 (rhombotin-like 1)
MECOM MDS1 and EVI1 complex locus
MED18 mediator complex subunit 18
MIR144 microRNA 144
MIR451A microRNA 451a
MPL MPL proto-oncogene, thrombopoietin receptor
MPV17 MpV17 mitochondrial inner membrane protein
MTRF1 mitochondrial translational release factor 1
MTUS1 microtubule associated tumor suppressor 1
MYO1E myosin IE
MYSM1 Myb-like, SWIRM and MPN domains 1
NAGK N-acetylglucosamine kinase
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
NFE2 nuclear factor, erythroid 2
NFE2L2 nuclear factor, erythroid 2-like 2
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae)
OSTM1 osteopetrosis associated transmembrane protein 1
PDGFB platelet-derived growth factor beta polypeptide
PICALM phosphatidylinositol binding clathrin assembly protein
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PKLR pyruvate kinase, liver and RBC
POLG polymerase (DNA directed), gamma
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R15B protein phosphatase 1, regulatory subunit 15B
PRDX1 peroxiredoxin 1
PRDX2 peroxiredoxin 2
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PTCH2 patched 2
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RIC1 RAB6A GEF complex partner 1
RNF10 ring finger protein 10
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
SCARF2 scavenger receptor class F, member 2
SGPL1 sphingosine-1-phosphate lyase 1
SHH sonic hedgehog
SIN3B SIN3 transcription regulator family member B
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC38A10 solute carrier family 38, member 10
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAP1 small ArfGAP 1
SNAI2 snail family zinc finger 2
SOD1 superoxide dismutase 1, soluble
SPP1 secreted phosphoprotein 1
SPTA1 spectrin, alpha, erythrocytic 1
SPTB spectrin, beta, erythrocytic
STARD13 StAR-related lipid transfer (START) domain containing 13
STEAP3 STEAP family member 3, metalloreductase
TAL1 T-cell acute lymphocytic leukemia 1
TF transferrin
THRB thyroid hormone receptor, beta
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TMEM189 transmembrane protein 189
TMEM68 transmembrane protein 68
TMPRSS6 transmembrane protease, serine 6
TNIP1 TNFAIP3 interacting protein 1
TPI1 triosephosphate isomerase 1
TTC7A tetratricopeptide repeat domain 7A
UMOD uromodulin
VANGL2 VANGL planar cell polarity protein 2
VNN1 vanin 1
XBP1 X-box binding protein 1
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36L2 ZFP36 ring finger protein-like 2