decreased granulocyte number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000334
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Genes

140 gene mutations causing the decreased granulocyte number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACVR2A activin A receptor, type IIA
ARHGAP15 Rho GTPase activating protein 15
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARID4A AT rich interactive domain 4A (RBP1-like)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASXL1 additional sex combs like transcriptional regulator 1
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
BAG3 BCL2-associated athanogene 3
BCL6B B-cell CLL/lymphoma 6, member B
BHLHE41 basic helix-loop-helix family, member e41
BTK Bruton agammaglobulinemia tyrosine kinase
C3 complement component 3
C3AR1 complement component 3a receptor 1
CCL11 chemokine (C-C motif) ligand 11
CCL3L3 chemokine (C-C motif) ligand 3-like 3
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR3 chemokine (C-C motif) receptor 3
CCR4 chemokine (C-C motif) receptor 4
CD101 CD101 molecule
CD19 CD19 molecule
CD34 CD34 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CERK ceramide kinase
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CLEC4E C-type lectin domain family 4, member E
CNN2 calponin 2
CPA3 carboxypeptidase A3 (mast cell)
CR2 complement component (3d/Epstein Barr virus) receptor 2
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CXCL6 chemokine (C-X-C motif) ligand 6
E2F4 E2F transcription factor 4, p107/p130-binding
EP300 E1A binding protein p300
F3 coagulation factor III (thromboplastin, tissue factor)
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FASTK Fas-activated serine/threonine kinase
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FHIT fragile histidine triad
G6PC3 glucose 6 phosphatase, catalytic, 3
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GALC galactosylceramidase
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GATA1 GATA binding protein 1 (globin transcription factor 1)
GFI1 growth factor independent 1 transcription repressor
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNMT glycine N-methyltransferase
GPC2 glypican 2
GSX1 GS homeobox 1
HAX1 HCLS1 associated protein X-1
HDC histidine decarboxylase
HMGN5 high mobility group nucleosome binding domain 5
IFITM1 interferon induced transmembrane protein 1
IFNB1 interferon, beta 1, fibroblast
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL13 interleukin 13
IL17A interleukin 17A
IL17RA interleukin 17 receptor A
IL17RB interleukin 17 receptor B
IL1R1 interleukin 1 receptor, type I
IL1RL1 interleukin 1 receptor-like 1
IL1RL2 interleukin 1 receptor-like 2
IL21R interleukin 21 receptor
IL22 interleukin 22
IL23A interleukin 23, alpha subunit p19
IL25 interleukin 25
IL33 interleukin 33
IL4 interleukin 4
IL5 interleukin 5
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB7 integrin, beta 7
KERA keratocan
KISS1R KISS1 receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
LGALS3 lectin, galactoside-binding, soluble, 3
LMO2 LIM domain only 2 (rhombotin-like 1)
LTB4R leukotriene B4 receptor
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LUM lumican
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MFAP5 microfibrillar associated protein 5
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MINA MYC induced nuclear antigen
MITF microphthalmia-associated transcription factor
MSI2 musashi RNA-binding protein 2
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
NAMPT nicotinamide phosphoribosyltransferase
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NLRP12 NLR family, pyrin domain containing 12
NOS2 nitric oxide synthase 2, inducible
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLA2G10 phospholipase A2, group X
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1
PLSCR1 phospholipid scramblase 1
PML promyelocytic leukemia
PRF1 perforin 1 (pore forming protein)
PRKCD protein kinase C, delta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTRH2 peptidyl-tRNA hydrolase 2
RAB27A RAB27A, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAG1 recombination activating gene 1
SAMD9L sterile alpha motif domain containing 9-like
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SGPL1 sphingosine-1-phosphate lyase 1
SIN3B SIN3 transcription regulator family member B
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SOCS1 suppressor of cytokine signaling 1
SPI1 Spi-1 proto-oncogene
SRGN serglycin
STAT5A signal transducer and activator of transcription 5A
STX11 syntaxin 11
TBK1 TANK-binding kinase 1
TET1 tet methylcytosine dioxygenase 1
TLR5 toll-like receptor 5
TP53 tumor protein p53
TREM1 triggering receptor expressed on myeloid cells 1
TRIB1 tribbles pseudokinase 1
ZEB1 zinc finger E-box binding homeobox 1
ZFP36L2 ZFP36 ring finger protein-like 2