decreased germinal center b cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen (Mammalian Phenotype Ontology, MP_0008178)
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18 gene mutations causing the decreased germinal center b cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BATF basic leucine zipper transcription factor, ATF-like
BCL6 B-cell CLL/lymphoma 6
CD274 CD274 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD84 CD84 molecule
CDH17 cadherin 17, LI cadherin (liver-intestine)
DOCK8 dedicator of cytokinesis 8
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
ICOS inducible T-cell co-stimulator
IL21 interleukin 21
LTB lymphotoxin beta (TNF superfamily, member 3)
MIR155 microRNA 155
MIR210 microRNA 210
SH2D1A SH2 domain containing 1A
TNF tumor necrosis factor
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
ZEB1 zinc finger E-box binding homeobox 1