decreased germ cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated (Mammalian Phenotype Ontology, MP_0002209)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002209
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Genes

363 gene mutations causing the decreased germ cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACVR2A activin A receptor, type IIA
ADAD1 adenosine deaminase domain containing 1 (testis-specific)
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2
ADGRG2 adhesion G protein-coupled receptor G2
ADIPOR2 adiponectin receptor 2
ADRA1B adrenoceptor alpha 1B
ADRM1 adhesion regulating molecule 1
AFF4 AF4/FMR2 family, member 4
AGFG1 ArfGAP with FG repeats 1
AGO4 argonaute RISC catalytic component 4
AGPS alkylglycerone phosphate synthase
AGTPBP1 ATP/GTP binding protein 1
AHR aryl hydrocarbon receptor
AK7 adenylate kinase 7
AKAP9 A kinase (PRKA) anchor protein 9
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ALKBH5 AlkB family member 5, RNA demethylase
APAF1 apoptotic peptidase activating factor 1
APOB apolipoprotein B
AR androgen receptor
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARL4A ADP-ribosylation factor-like 4A
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAT1 alpha tubulin acetyltransferase 1
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
AURKB aurora kinase B
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L2 BCL2-like 2
BCL6 B-cell CLL/lymphoma 6
BGLAP bone gamma-carboxyglutamate (gla) protein
BMP15 bone morphogenetic protein 15
BMP4 bone morphogenetic protein 4
BMP8B bone morphogenetic protein 8b
BOLL boule-like RNA-binding protein
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRDT bromodomain, testis-specific
BRWD1 bromodomain and WD repeat domain containing 1
BSG basigin (Ok blood group)
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CADM1 cell adhesion molecule 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CATSPERD catsper channel auxiliary subunit delta
CBX3 chromobox homolog 3
CCDC169-SOHLH2 CCDC169-SOHLH2 readthrough
CCDC79 coiled-coil domain containing 79
CCNA1 cyclin A1
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCND2 cyclin D2
CCNE2 cyclin E2
CD59 CD59 molecule, complement regulatory protein
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CELF3 CUGBP, Elav-like family member 3
CENPB centromere protein B, 80kDa
CHD5 chromodomain helicase DNA binding protein 5
CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
CIB1 calcium and integrin binding 1 (calmyrin)
CIT citron rho-interacting serine/threonine kinase
CKS2 CDC28 protein kinase regulatory subunit 2
CLCN2 chloride channel, voltage-sensitive 2
CLDN11 claudin 11
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit
CNBD2 cyclic nucleotide binding domain containing 2
CNOT7 CCR4-NOT transcription complex, subunit 7
CPEB1 cytoplasmic polyadenylation element binding protein 1
CREB3L4 cAMP responsive element binding protein 3-like 4
CREM cAMP responsive element modulator
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CTDNEP1 CTD nuclear envelope phosphatase 1
CUL4A cullin 4A
CXCR4 chemokine (C-X-C motif) receptor 4
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DAZ2 deleted in azoospermia 2
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DHH desert hedgehog
DMC1 DNA meiotic recombinase 1
DMRT1 doublesex and mab-3 related transcription factor 1
DMRTC2 DMRT-like family C2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DND1 DND microRNA-mediated repression inhibitor 1
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like
E2F6 E2F transcription factor 6
EGR1 early growth response 1
EGR4 early growth response 4
EHD1 EH-domain containing 1
EHD4 EH-domain containing 4
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
ENO4 enolase family member 4
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ESR1 estrogen receptor 1
ETV5 ets variant 5
EXO1 exonuclease 1
FADS2 fatty acid desaturase 2
FANCA Fanconi anemia, complementation group A
FANCC Fanconi anemia, complementation group C
FANCD2 Fanconi anemia, complementation group D2
FANCL Fanconi anemia, complementation group L
FANCM Fanconi anemia, complementation group M
FHL5 four and a half LIM domains 5
FIGLA folliculogenesis specific basic helix-loop-helix
FKBP4 FK506 binding protein 4, 59kDa
FKBP6 FK506 binding protein 6, 36kDa
FOXC1 forkhead box C1
FOXP3 forkhead box P3
FSHB follicle stimulating hormone, beta polypeptide
FSHR follicle stimulating hormone receptor
FYN FYN proto-oncogene, Src family tyrosine kinase
GAL3ST1 galactose-3-O-sulfotransferase 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5
GAMT guanidinoacetate N-methyltransferase
GBA2 glucosidase, beta (bile acid) 2
GGT1 gamma-glutamyltransferase 1
GJA1 gap junction protein, alpha 1, 43kDa
GMCL1 germ cell-less, spermatogenesis associated 1
GNPAT glyceronephosphate O-acyltransferase
GNRHR gonadotropin-releasing hormone receptor
GOLGA3 golgin A3
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTSF1 gametocyte specific factor 1
H1FNT H1 histone family, member N, testis-specific
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HIP1 huntingtin interacting protein 1
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HORMAD1 HORMA domain containing 1
HORMAD2 HORMA domain containing 2
HOXA10 homeobox A10
HOXA11 homeobox A11
HSF2 heat shock transcription factor 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA4 heat shock 70kDa protein 4
HSPA4L heat shock 70kDa protein 4-like
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
ING2 inhibitor of growth family, member 2
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
INSL3 insulin-like 3 (Leydig cell)
INSL6 insulin-like 6
IP6K1 inositol hexakisphosphate kinase 1
IRS2 insulin receptor substrate 2
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
JMJD1C jumonji domain containing 1C
JUND jun D proto-oncogene
KATNAL1 katanin p60 subunit A-like 1
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
KDM2B lysine (K)-specific demethylase 2B
KDM3A lysine (K)-specific demethylase 3A
KIAA1524 KIAA1524
KISS1 KiSS-1 metastasis-suppressor
KISS1R KISS1 receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KL klotho
KLHL10 kelch-like family member 10
LARP7 La ribonucleoprotein domain family, member 7
LEPR leptin receptor
LHB luteinizing hormone beta polypeptide
LHCGR luteinizing hormone/choriogonadotropin receptor
LHX3 LIM homeobox 3
LIN28A lin-28 homolog A (C. elegans)
LIPE lipase, hormone-sensitive
LMNA lamin A/C
LMTK2 lemur tyrosine kinase 2
LOC101929327
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
M1AP meiosis 1 associated protein
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)
MAN2A2 mannosidase, alpha, class 2A, member 2
MAP2 microtubule-associated protein 2
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP7 microtubule-associated protein 7
MCM8 minichromosome maintenance complex component 8
MCM9 minichromosome maintenance complex component 9
MCPH1 microcephalin 1
MDC1 mediator of DNA-damage checkpoint 1
MEI1 meiosis inhibitor 1
MEI4 meiosis-specific 4 homolog (S. cerevisiae)
MEIG1 meiosis/spermiogenesis associated 1
MEIOB meiosis specific with OB domains
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MLH1 mutL homolog 1
MLH3 mutL homolog 3
MNS1 meiosis-specific nuclear structural 1
MORC1 MORC family CW-type zinc finger 1
MOV10L1 Mov10 RISC complex RNA helicase like 1
MSH4 mutS homolog 4
MSH5 mutS homolog 5
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NANOS2 nanos homolog 2 (Drosophila)
NANOS3 nanos homolog 3 (Drosophila)
NBN nibrin
NHLH2 nescient helix loop helix 2
NKD1 naked cuticle homolog 1 (Drosophila)
NME5 NME/NM23 family member 5
NOBOX NOBOX oogenesis homeobox
NPC1 Niemann-Pick disease, type C1
NPEPPS aminopeptidase puromycin sensitive
NPHP1 nephronophthisis 1 (juvenile)
NPHP4 nephronophthisis 4
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR2C2 nuclear receptor subfamily 2, group C, member 2
NR5A1 nuclear receptor subfamily 5, group A, member 1
NUP210L nucleoporin 210kDa-like
NUPR1 nuclear protein, transcriptional regulator, 1
NXF2 nuclear RNA export factor 2
OCA2 oculocutaneous albinism II
ODF1 outer dense fiber of sperm tails 1
OPRM1 opioid receptor, mu 1
OVOL1 ovo-like zinc finger 1
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PABPC1L poly(A) binding protein, cytoplasmic 1-like
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PANK2 pantothenate kinase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCNA proliferating cell nuclear antigen
PDS5B PDS5 cohesin associated factor B
PEG3 paternally expressed 3
PEPD peptidase D
PFDN5 prefoldin subunit 5
PHF13 PHD finger protein 13
PICK1 protein interacting with PRKCA 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PIWIL1 piwi-like RNA-mediated gene silencing 1
PIWIL2 piwi-like RNA-mediated gene silencing 2
PIWIL4 piwi-like RNA-mediated gene silencing 4
PLD6 phospholipase D family, member 6
PLK4 polo-like kinase 4
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POLG polymerase (DNA directed), gamma
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PRDM1 PR domain containing 1, with ZNF domain
PRDM14 PR domain containing 14
PRDM9 PR domain containing 9
PRDX4 peroxiredoxin 4
PRND prion protein 2 (dublet)
PROKR2 prokineticin receptor 2
PRSS21 protease, serine, 21 (testisin)
PSAP prosaposin
PSMC3IP PSMC3 interacting protein
PUM1 pumilio RNA-binding family member 1
QKI QKI, KH domain containing, RNA binding
RABL2A RAB, member of RAS oncogene family-like 2A
RAD18 RAD18 E3 ubiquitin protein ligase
RAD21L1 RAD21-like 1 (S. pombe)
RAD51C RAD51 paralog C
RANBP1 RAN binding protein 1
RANBP9 RAN binding protein 9
RARA retinoic acid receptor, alpha
RBM5 RNA binding motif protein 5
REC8 REC8 meiotic recombination protein
REST RE1-silencing transcription factor
RIMBP3 RIMS binding protein 3
RLN1 relaxin 1
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF17 ring finger protein 17
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
ROR2 receptor tyrosine kinase-like orphan receptor 2
RSPH1 radial spoke head 1 homolog (Chlamydomonas)
RSPO1 R-spondin 1
RXFP1 relaxin/insulin-like family peptide receptor 1
RXFP2 relaxin/insulin-like family peptide receptor 2
RXRB retinoid X receptor, beta
SAFB scaffold attachment factor B
SBF1 SET binding factor 1
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SEPT12 septin 12
SGOL2 shugoshin-like 2 (S. pombe)
SH2B1 SH2B adaptor protein 1
SIAH1 siah E3 ubiquitin protein ligase 1
SIRT1 sirtuin 1
SIX5 SIX homeobox 5
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLX4 SLX4 structure-specific endonuclease subunit
SMAD1 SMAD family member 1
SMAD5 SMAD family member 5
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
SMC1B structural maintenance of chromosomes 1B
SOX2 SRY (sex determining region Y)-box 2
SOX3 SRY (sex determining region Y)-box 3
SPAG16 sperm associated antigen 16
SPAG9 sperm associated antigen 9
SPATA22 spermatogenesis associated 22
SPEF2 sperm flagellar 2
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPO11 SPO11 meiotic protein covalently bound to DSB
STAG3 stromal antigen 3
STRA8 stimulated by retinoic acid 8
STRBP spermatid perinuclear RNA binding protein
STX2 syntaxin 2
SUN1 Sad1 and UNC84 domain containing 1
SYCE1 synaptonemal complex central element protein 1
SYCE3 synaptonemal complex central element protein 3
SYCP1 synaptonemal complex protein 1
SYCP2 synaptonemal complex protein 2
SYCP3 synaptonemal complex protein 3
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
TARBP2 TAR (HIV-1) RNA binding protein 2
TASP1 taspase, threonine aspartase, 1
TBC1D20 TBC1 domain family, member 20
TBPL1 TBP-like 1
TCTE3 t-complex-associated-testis-expressed 3
TDRD1 tudor domain containing 1
TDRD6 tudor domain containing 6
TDRD9 tudor domain containing 9
TDRKH tudor and KH domain containing
TET1 tet methylcytosine dioxygenase 1
TEX12 testis expressed 12
TEX15 testis expressed 15
TGFB2 transforming growth factor, beta 2
THEG theg spermatid protein
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TNF tumor necrosis factor
TP73 tumor protein p73
TPST2 tyrosylprotein sulfotransferase 2
TRIP13 thyroid hormone receptor interactor 13
TSC22D3 TSC22 domain family, member 3
TSN translin
TSSK6 testis-specific serine kinase 6
TTLL1 tubulin tyrosine ligase-like family member 1
UBB ubiquitin B
UBE2B ubiquitin-conjugating enzyme E2B
UBE3A ubiquitin protein ligase E3A
UBR2 ubiquitin protein ligase E3 component n-recognin 2
USP1 ubiquitin specific peptidase 1
UTP14C UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
VRK1 vaccinia related kinase 1
WDR48 WD repeat domain 48
WNT4 wingless-type MMTV integration site family, member 4
WNT5A wingless-type MMTV integration site family, member 5A
WT1 Wilms tumor 1
YBX2 Y box binding protein 2
YBX3 Y box binding protein 3
ZBTB16 zinc finger and BTB domain containing 16
ZC3HC1 zinc finger, C3HC-type containing 1
ZFP42 ZFP42 zinc finger protein
ZFX zinc finger protein, X-linked
ZGLP1 zinc finger, GATA-like protein 1