decreased follicular b cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes (Mammalian Phenotype Ontology, MP_0008174)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008174
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Genes

37 gene mutations causing the decreased follicular b cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AIRE autoimmune regulator
APOE apolipoprotein E
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATP11C ATPase, class VI, type 11C
BCL10 B-cell CLL/lymphoma 10
BCL3 B-cell CLL/lymphoma 3
BIRC3 baculoviral IAP repeat containing 3
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
CD5 CD5 molecule
CD72 CD72 molecule
CR2 complement component (3d/Epstein Barr virus) receptor 2
FLI1 Fli-1 proto-oncogene, ETS transcription factor
IGHM immunoglobulin heavy constant mu
IRF8 interferon regulatory factor 8
KLHL6 kelch-like family member 6
LYN LYN proto-oncogene, Src family tyrosine kinase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PGM3 phosphoglucomutase 3
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SFN stratifin
SIAE sialic acid acetylesterase
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SPNS2 spinster homolog 2 (Drosophila)
SPPL2A signal peptide peptidase like 2A
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
ZBTB1 zinc finger and BTB domain containing 1