decreased double-negative t cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 (Mammalian Phenotype Ontology, MP_0005089)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005089
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Genes

40 gene mutations causing the decreased double-negative t cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CDK6 cyclin-dependent kinase 6
DCLRE1C DNA cross-link repair 1C
FLT3LG fms-related tyrosine kinase 3 ligand
FOXN1 forkhead box N1
GATA3 GATA binding protein 3
GFI1 growth factor independent 1 transcription repressor
GPR15 G protein-coupled receptor 15
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL2 interleukin 2
IL2RG interleukin 2 receptor, gamma
KAT6A K(lysine) acetyltransferase 6A
KITLG KIT ligand
KMT2E lysine (K)-specific methyltransferase 2E
LAT linker for activation of T cells
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LIG4 ligase IV, DNA, ATP-dependent
LRFN2 leucine rich repeat and fibronectin type III domain containing 2
MCL1 myeloid cell leukemia 1
MCM4 minichromosome maintenance complex component 4
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MSI2 musashi RNA-binding protein 2
NCAPH2 non-SMC condensin II complex, subunit H2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH1 notch 1
PAX1 paired box 1
PRKCH protein kinase C, eta
PRKCQ protein kinase C, theta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTCRA pre T-cell antigen receptor alpha
RAD50 RAD50 homolog (S. cerevisiae)
RAG2 recombination activating gene 2
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RORC RAR-related orphan receptor C
RPL22 ribosomal protein L22
SPI1 Spi-1 proto-oncogene
SYK spleen tyrosine kinase
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
VAV1 vav 1 guanine nucleotide exchange factor
ZBTB1 zinc finger and BTB domain containing 1