decreased dopamine level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description less than the normal amount of this catecholamine neurotransmitter and neurohormone, derived from tyrosine and the precursor to norepinephrine and epinephrine; functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary (Mammalian Phenotype Ontology, MP_0005643)
External Link
Similar Terms
Downloads & Tools


29 gene mutations causing the decreased dopamine level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DRD3 dopamine receptor D3
ESR2 estrogen receptor 2 (ER beta)
FOXP2 forkhead box P2
GJB6 gap junction protein, beta 6, 30kDa
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HIPK2 homeodomain interacting protein kinase 2
HPRT1 hypoxanthine phosphoribosyltransferase 1
IL6 interleukin 6
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
MDK midkine (neurite growth-promoting factor 2)
NENF neudesin neurotrophic factor
NR4A2 nuclear receptor subfamily 4, group A, member 2
PINK1 PTEN induced putative kinase 1
PITX3 paired-like homeodomain 3
PLAT plasminogen activator, tissue
PRL prolactin
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTS 6-pyruvoyltetrahydropterin synthase
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SSTR2 somatostatin receptor 2
TGFB2 transforming growth factor, beta 2
TH tyrosine hydroxylase
TNC tenascin C
TOR1A torsin family 1, member A (torsin A)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)