decreased cytotoxic t cell cytolysis Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description impaired ability of cytotoxic T cells to induce pathological breakdown of target cells by the destruction of their outer membrane (Mammalian Phenotype Ontology, MP_0005079)
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34 gene mutations causing the decreased cytotoxic t cell cytolysis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BATF3 basic leucine zipper transcription factor, ATF-like 3
CD226 CD226 molecule
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD7 CD7 molecule
CHRM1 cholinergic receptor, muscarinic 1
ELF4 E74-like factor 4 (ets domain transcription factor)
FASLG Fas ligand (TNF superfamily, member 6)
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
IL2 interleukin 2
IL21R interleukin 21 receptor
IL6 interleukin 6
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
LCK LCK proto-oncogene, Src family tyrosine kinase
LYST lysosomal trafficking regulator
MBTPS1 membrane-bound transcription factor peptidase, site 1
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PNLIPRP2 pancreatic lipase-related protein 2
PNP purine nucleoside phosphorylase
PRF1 perforin 1 (pore forming protein)
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
PTPRC protein tyrosine phosphatase, receptor type, C
RAB27A RAB27A, member RAS oncogene family
RABGGTA Rab geranylgeranyltransferase, alpha subunit
REL v-rel avian reticuloendotheliosis viral oncogene homolog
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
STX11 syntaxin 11
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TOX thymocyte selection-associated high mobility group box
UNC13D unc-13 homolog D (C. elegans)
XCL1 chemokine (C motif) ligand 1