decreased common myeloid progenitor cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages (Mammalian Phenotype Ontology, MP_0008813)
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37 gene mutations causing the decreased common myeloid progenitor cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADAR adenosine deaminase, RNA-specific
ANK1 ankyrin 1, erythrocytic
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ATF4 activating transcription factor 4
BRCA2 breast cancer 2, early onset
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CCR2 chemokine (C-C motif) receptor 2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CREBBP CREB binding protein
CXCL12 chemokine (C-X-C motif) ligand 12
DKC1 dyskeratosis congenita 1, dyskerin
ERCC1 excision repair cross-complementation group 1
FANCC Fanconi anemia, complementation group C
GATA2 GATA binding protein 2
HIP1 huntingtin interacting protein 1
IFNB1 interferon, beta 1, fibroblast
IL6ST interleukin 6 signal transducer
JAK2 Janus kinase 2
KAT6A K(lysine) acetyltransferase 6A
KIAA0101 KIAA0101
KMT2A lysine (K)-specific methyltransferase 2A
KMT2E lysine (K)-specific methyltransferase 2E
LIF leukemia inhibitory factor
MEIS1 Meis homeobox 1
MPL MPL proto-oncogene, thrombopoietin receptor
MSI2 musashi RNA-binding protein 2
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
PBX1 pre-B-cell leukemia homeobox 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLX4 SLX4 structure-specific endonuclease subunit
SOD1 superoxide dismutase 1, soluble
SPI1 Spi-1 proto-oncogene
TAL1 T-cell acute lymphocytic leukemia 1
TP53 tumor protein p53