decreased circulating testosterone level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the blood concentration of a potent androgen that promotes development of male secondary sex characteristics and the development of spermatozoa and may regulate sexual desire and help maintain bone and muscle health in both males and females (Mammalian Phenotype Ontology, MP_0002780)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002780
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Genes

42 gene mutations causing the decreased circulating testosterone level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADRA1B adrenoceptor alpha 1B
AR androgen receptor
BGLAP bone gamma-carboxyglutamate (gla) protein
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CGA glycoprotein hormones, alpha polypeptide
CSF1 colony stimulating factor 1 (macrophage)
CUX1 cut-like homeobox 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DDR2 discoidin domain receptor tyrosine kinase 2
DHH desert hedgehog
EGR1 early growth response 1
ESR1 estrogen receptor 1
FSHR follicle stimulating hormone receptor
GHR growth hormone receptor
GNRHR gonadotropin-releasing hormone receptor
GPRC6A G protein-coupled receptor, class C, group 6, member A
IRS2 insulin receptor substrate 2
KISS1 KiSS-1 metastasis-suppressor
KISS1R KISS1 receptor
LEP leptin
LHB luteinizing hormone beta polypeptide
LHCGR luteinizing hormone/choriogonadotropin receptor
LHX9 LIM homeobox 9
LIN28A lin-28 homolog A (C. elegans)
MAGEL2 melanoma antigen family L2
NCOA1 nuclear receptor coactivator 1
NHLH2 nescient helix loop helix 2
NPEPPS aminopeptidase puromycin sensitive
NPR1 natriuretic peptide receptor 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR5A2 nuclear receptor subfamily 5, group A, member 2
OTX1 orthodenticle homeobox 1
PEPD peptidase D
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PROKR2 prokineticin receptor 2
SAFB scaffold attachment factor B
SGPL1 sphingosine-1-phosphate lyase 1
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
VIP vasoactive intestinal peptide
WWOX WW domain containing oxidoreductase