decreased circulating leptin level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance (Mammalian Phenotype Ontology, MP_0005668)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005668
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Genes

86 gene mutations causing the decreased circulating leptin level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACACB acetyl-CoA carboxylase beta
ACSS1 acyl-CoA synthetase short-chain family member 1
ACTB actin, beta
ADCY3 adenylate cyclase 3
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AGRP agouti related neuropeptide
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ANKRD11 ankyrin repeat domain 11
APOE apolipoprotein E
ARRDC3 arrestin domain containing 3
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C3 complement component 3
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CERS6 ceramide synthase 6
CHRM3 cholinergic receptor, muscarinic 3
CIDEB cell death-inducing DFFA-like effector b
CIDEC cell death-inducing DFFA-like effector c
CNR1 cannabinoid receptor 1 (brain)
CRBN cereblon
CRH corticotropin releasing hormone
CRTC3 CREB regulated transcription coactivator 3
DGAT1 diacylglycerol O-acyltransferase 1
DMBX1 diencephalon/mesencephalon homeobox 1
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FFAR3 free fatty acid receptor 3
FTO fat mass and obesity associated
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCGR glucagon receptor
GNAS GNAS complex locus
GNG3 guanine nucleotide binding protein (G protein), gamma 3
HAP1 huntingtin-associated protein 1
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INPP5K inositol polyphosphate-5-phosphatase K
INPPL1 inositol polyphosphate phosphatase-like 1
INS insulin
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
LEPR leptin receptor
LGALS12 lectin, galactoside-binding, soluble, 12
LIPE lipase, hormone-sensitive
LMNA lamin A/C
LPIN1 lipin 1
MAPK8 mitogen-activated protein kinase 8
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MCHR1 melanin-concentrating hormone receptor 1
MSTN myostatin
NCOR2 nuclear receptor corepressor 2
NMUR2 neuromedin U receptor 2
NOS2 nitric oxide synthase 2, inducible
PDE10A phosphodiesterase 10A
PLA2G1B phospholipase A2, group IB (pancreas)
PLIN1 perilipin 1
PLIN2 perilipin 2
PMCH pro-melanin-concentrating hormone
PNRC2 proline-rich nuclear receptor coactivator 2
PPARG peroxisome proliferator-activated receptor gamma
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRLR prolactin receptor
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTRF polymerase I and transcript release factor
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RLN3 relaxin 3
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
SERTAD2 SERTA domain containing 2
SIK3 SIK family kinase 3
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SOCS3 suppressor of cytokine signaling 3
SSFA2 sperm specific antigen 2
TGFB1 transforming growth factor, beta 1
TLR2 toll-like receptor 2
TNF tumor necrosis factor
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
ZBTB20 zinc finger and BTB domain containing 20