decreased circulating ldl cholesterol level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced amount in the blood of the lipoprotein:cholesterol complex that transports cholesterol out of the arteries and around the body, for use by various tissues in normal bodily functions (Mammalian Phenotype Ontology, MP_0000183)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000183
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Genes

50 gene mutations causing the decreased circulating ldl cholesterol level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACTB actin, beta
ADIPOR2 adiponectin receptor 2
AKAP9 A kinase (PRKA) anchor protein 9
ANGPTL3 angiopoietin-like 3
APOA1 apolipoprotein A-I
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APOE apolipoprotein E
CBX6 chromobox homolog 6
CDH23 cadherin-related 23
CHD7 chromodomain helicase DNA binding protein 7
DBN1 drebrin 1
GHR growth hormone receptor
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LPIN1 lipin 1
LPL lipoprotein lipase
MALRD1 MAM and LDL receptor class A domain containing 1
MOGAT2 monoacylglycerol O-acyltransferase 2
MTA1 metastasis associated 1
MTTP microsomal triglyceride transfer protein
MYO6 myosin VI
MYO7A myosin VIIA
MYSM1 Myb-like, SWIRM and MPN domains 1
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR2C2 nuclear receptor subfamily 2, group C, member 2
NSUN2 NOP2/Sun RNA methyltransferase family, member 2
OED Oregon eye disease
OSTM1 osteopetrosis associated transmembrane protein 1
P2RY13 purinergic receptor P2Y, G-protein coupled, 13
PCSK9 proprotein convertase subtilisin/kexin type 9
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PON2 paraoxonase 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
SAR1B secretion associated, Ras related GTPase 1B
SEC16B SEC16 homolog B (S. cerevisiae)
SEC24A SEC24 family member A
SETD1A SET domain containing 1A
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SOAT2 sterol O-acyltransferase 2
STARD4 StAR-related lipid transfer (START) domain containing 4
SYT1 synaptotagmin I
TBC1D10A TBC1 domain family, member 10A
TMC6 transmembrane channel-like 6
TRPC3 transient receptor potential cation channel, subfamily C, member 3
UBE3B ubiquitin protein ligase E3B
UTS2 urotensin 2
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble