decreased circulating interleukin-4 level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells (Mammalian Phenotype Ontology, MP_0008603)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008603
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Genes

14 gene mutations causing the decreased circulating interleukin-4 level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CARD11 caspase recruitment domain family, member 11
CCR3 chemokine (C-C motif) receptor 3
CD19 CD19 molecule
CD28 CD28 molecule
CXCL16 chemokine (C-X-C motif) ligand 16
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
GATA1 GATA binding protein 1 (globin transcription factor 1)
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
ICOS inducible T-cell co-stimulator
IL2 interleukin 2
MAP3K14 mitogen-activated protein kinase kinase kinase 14
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
TSLP thymic stromal lymphopoietin