decreased circulating interleukin-1 alpha level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the amount in the blood of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active (Mammalian Phenotype Ontology, MP_0008639)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008639
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Genes

4 gene mutations causing the decreased circulating interleukin-1 alpha level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CASP4 caspase 4, apoptosis-related cysteine peptidase
IL1A interleukin 1, alpha
IL22 interleukin 22
TNF tumor necrosis factor