decreased circulating interferon-gamma level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation (Mammalian Phenotype Ontology, MP_0008578)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008578
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Genes

26 gene mutations causing the decreased circulating interferon-gamma level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ATF2 activating transcription factor 2
CCR1 chemokine (C-C motif) receptor 1
CD19 CD19 molecule
CD28 CD28 molecule
CXCL16 chemokine (C-X-C motif) ligand 16
FLT3 fms-related tyrosine kinase 3
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
ICOS inducible T-cell co-stimulator
IFNGR1 interferon gamma receptor 1
IL12A interleukin 12A
IL12B interleukin 12B
IL12RB1 interleukin 12 receptor, beta 1
IL18 interleukin 18
IL2 interleukin 2
IL27RA interleukin 27 receptor, alpha
IRAK4 interleukin-1 receptor-associated kinase 4
IRF1 interferon regulatory factor 1
LTA lymphotoxin alpha
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAVS mitochondrial antiviral signaling protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT4 signal transducer and activator of transcription 4
TICAM1 toll-like receptor adaptor molecule 1
TNF tumor necrosis factor
TRPM2 transient receptor potential cation channel, subfamily M, member 2
USP18 ubiquitin specific peptidase 18