decreased circulating insulin level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description less than normal levels of insulin in the blood (Mammalian Phenotype Ontology, MP_0002727)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002727
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Genes

183 gene mutations causing the decreased circulating insulin level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACTB actin, beta
ADCY3 adenylate cyclase 3
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ADIPOR2 adiponectin receptor 2
AHSG alpha-2-HS-glycoprotein
AKAP5 A kinase (PRKA) anchor protein 5
AKT2 v-akt murine thymoma viral oncogene homolog 2
APOA2 apolipoprotein A-II
ARRDC3 arrestin domain containing 3
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
AZIN2 antizyme inhibitor 2
BAD BCL2-associated agonist of cell death
BAG3 BCL2-associated athanogene 3
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BGLAP bone gamma-carboxyglutamate (gla) protein
C3 complement component 3
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX6 chromobox homolog 6
CCDC80 coiled-coil domain containing 80
CCL13 chemokine (C-C motif) ligand 13
CD38 CD38 molecule
CDK4 cyclin-dependent kinase 4
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CERS6 ceramide synthase 6
CHD7 chromodomain helicase DNA binding protein 7
CHRM3 cholinergic receptor, muscarinic 3
CNR1 cannabinoid receptor 1 (brain)
COL1A1 collagen, type I, alpha 1
COL5A3 collagen, type V, alpha 3
CRBN cereblon
CRTC2 CREB regulated transcription coactivator 2
CRTC3 CREB regulated transcription coactivator 3
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5R4 cytochrome b5 reductase 4
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
E2F1 E2F transcription factor 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ERCC1 excision repair cross-complementation group 1
FABP1 fatty acid binding protein 1, liver
FABP4 fatty acid binding protein 4, adipocyte
FFAR1 free fatty acid receptor 1
FFAR2 free fatty acid receptor 2
FGF23 fibroblast growth factor 23
FOXA1 forkhead box A1
FTO fat mass and obesity associated
G0S2 G0/G1 switch 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCG glucagon
GCGR glucagon receptor
GCK glucokinase (hexokinase 4)
GCKR glucokinase (hexokinase 4) regulator
GHR growth hormone receptor
GIPR gastric inhibitory polypeptide receptor
GLIS3 GLIS family zinc finger 3
GLP1R glucagon-like peptide 1 receptor
GNAS GNAS complex locus
GPAM glycerol-3-phosphate acyltransferase, mitochondrial
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPR39 G protein-coupled receptor 39
GPR68 G protein-coupled receptor 68
GPRC6A G protein-coupled receptor, class C, group 6, member A
GSK3B glycogen synthase kinase 3 beta
GYS2 glycogen synthase 2 (liver)
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HMGA1 high mobility group AT-hook 1
HMGN3 high mobility group nucleosomal binding domain 3
HNF1A HNF1 homeobox A
HRH1 histamine receptor H1
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IL10 interleukin 10
ILDR2 immunoglobulin-like domain containing receptor 2
INPP5K inositol polyphosphate-5-phosphatase K
INPPL1 inositol polyphosphate phosphatase-like 1
INS insulin
INSL5 insulin-like 5
IP6K1 inositol hexakisphosphate kinase 1
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KL klotho
KLB klotho beta
LCLAT1 lysocardiolipin acyltransferase 1
LEPR leptin receptor
LIPE lipase, hormone-sensitive
LMNA lamin A/C
LRP5 low density lipoprotein receptor-related protein 5
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
MAPK8 mitogen-activated protein kinase 8
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MARK4 MAP/microtubule affinity-regulating kinase 4
MBD5 methyl-CpG binding domain protein 5
MCHR1 melanin-concentrating hormone receptor 1
MGAM maltase-glucoamylase
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MGLL monoglyceride lipase
MIER1 mesoderm induction early response 1, transcriptional regulator
MOGAT2 monoacylglycerol O-acyltransferase 2
MSTN myostatin
NCOA3 nuclear receptor coactivator 3
NCOR2 nuclear receptor corepressor 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NPY2R neuropeptide Y receptor Y2
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR2C2 nuclear receptor subfamily 2, group C, member 2
OMA1 OMA1 zinc metallopeptidase
ONECUT1 one cut homeobox 1
PASK PAS domain containing serine/threonine kinase
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK2 proprotein convertase subtilisin/kexin type 2
PDE10A phosphodiesterase 10A
PDX1 pancreatic and duodenal homeobox 1
PFKM phosphofructokinase, muscle
PHOX2A paired-like homeobox 2a
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PITPNA phosphatidylinositol transfer protein, alpha
PLA2G1B phospholipase A2, group IB (pancreas)
PNLIP pancreatic lipase
PNPLA2 patatin-like phospholipase domain containing 2
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTTG1 pituitary tumor-transforming 1
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RBM4 RNA binding motif protein 4
RIMS2 regulating synaptic membrane exocytosis 2
RLN3 relaxin 3
RPS6 ribosomal protein S6
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SAMD4A sterile alpha motif domain containing 4A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC3 syndecan 3
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SERP1 stress-associated endoplasmic reticulum protein 1
SERTAD2 SERTA domain containing 2
SGMS1 sphingomyelin synthase 1
SH2B2 SH2B adaptor protein 2
SIDT2 SID1 transmembrane family, member 2
SIK3 SIK family kinase 3
SIRT1 sirtuin 1
SIRT6 sirtuin 6
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
SOX4 SRY (sex determining region Y)-box 4
SPP1 secreted phosphoprotein 1
SRA1 steroid receptor RNA activator 1
SSFA2 sperm specific antigen 2
SSTR5 somatostatin receptor 5
STEAP4 STEAP family member 4
TBC1D4 TBC1 domain family, member 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TGFB1 transforming growth factor, beta 1
TGM2 transglutaminase 2
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TMEM189 transmembrane protein 189
TNF tumor necrosis factor
TRH thyrotropin-releasing hormone
UCN3 urocortin 3
USH1C Usher syndrome 1C (autosomal recessive, severe)
VGF VGF nerve growth factor inducible
WFS1 Wolfram syndrome 1 (wolframin)
ZBTB20 zinc finger and BTB domain containing 20