decreased circulating gonadotropin level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description less than the normal blood concentration of the peptide hormones that stimulate gonadal functions such as gametogenesis and sex steroid hormone production in the ovary and the testis (Mammalian Phenotype Ontology, MP_0003363)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003363
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Genes

42 gene mutations causing the decreased circulating gonadotropin level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACVR2A activin A receptor, type IIA
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
AMH anti-Mullerian hormone
AR androgen receptor
CDK4 cyclin-dependent kinase 4
CGA glycoprotein hormones, alpha polypeptide
CLOCK clock circadian regulator
CORT cortistatin
CRTC1 CREB regulated transcription coactivator 1
ESR1 estrogen receptor 1
FOXN1 forkhead box N1
FSHB follicle stimulating hormone, beta polypeptide
GHR growth hormone receptor
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GNRHR gonadotropin-releasing hormone receptor
INHA inhibin, alpha
IRS2 insulin receptor substrate 2
JUND jun D proto-oncogene
KISS1 KiSS-1 metastasis-suppressor
KISS1R KISS1 receptor
LATS1 large tumor suppressor kinase 1
LHCGR luteinizing hormone/choriogonadotropin receptor
LHX3 LIM homeobox 3
LIN28A lin-28 homolog A (C. elegans)
MARK2 MAP/microtubule affinity-regulating kinase 2
NHLH2 nescient helix loop helix 2
NOS1 nitric oxide synthase 1 (neuronal)
NPC1 Niemann-Pick disease, type C1
NPEPPS aminopeptidase puromycin sensitive
NR1H3 nuclear receptor subfamily 1, group H, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OTX2 orthodenticle homeobox 2
PGR progesterone receptor
POU1F1 POU class 1 homeobox 1
PRL prolactin
PROP1 PROP paired-like homeobox 1
SIRT1 sirtuin 1
SOD1 superoxide dismutase 1, soluble
SST somatostatin
TRHR thyrotropin-releasing hormone receptor
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1
VIP vasoactive intestinal peptide