decreased circulating glucose level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source (Mammalian Phenotype Ontology, MP_0005560)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005560
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Genes

257 gene mutations causing the decreased circulating glucose level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD5 abhydrolase domain containing 5
ACACB acetyl-CoA carboxylase beta
ACADL acyl-CoA dehydrogenase, long chain
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACADVL acyl-CoA dehydrogenase, very long chain
ACER1 alkaline ceramidase 1
ACOT11 acyl-CoA thioesterase 11
ACSS1 acyl-CoA synthetase short-chain family member 1
ACTB actin, beta
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADRA2A adrenoceptor alpha 2A
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AKAP9 A kinase (PRKA) anchor protein 9
AKT2 v-akt murine thymoma viral oncogene homolog 2
APOA2 apolipoprotein A-II
APOE apolipoprotein E
AQP7 aquaporin 7
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARRDC3 arrestin domain containing 3
ARX aristaless related homeobox
ATF4 activating transcription factor 4
ATN1 atrophin 1
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
ATXN2 ataxin 2
AVPR2 arginine vasopressin receptor 2
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BAG3 BCL2-associated athanogene 3
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BRD2 bromodomain containing 2
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C3 complement component 3
CABP1 calcium binding protein 1
CBX6 chromobox homolog 6
CD36 CD36 molecule (thrombospondin receptor)
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDO1 cysteine dioxygenase type 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CES1 carboxylesterase 1
CHRM3 cholinergic receptor, muscarinic 3
CIDEC cell death-inducing DFFA-like effector c
CLCN3 chloride channel, voltage-sensitive 3
CNOT3 CCR4-NOT transcription complex, subunit 3
COL1A1 collagen, type I, alpha 1
CPE carboxypeptidase E
CPT1A carnitine palmitoyltransferase 1A (liver)
CRBN cereblon
CRTC2 CREB regulated transcription coactivator 2
CXCL14 chemokine (C-X-C motif) ligand 14
CYB561 cytochrome b561
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DBN1 drebrin 1
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DERL2 derlin 2
DFNB31 deafness, autosomal recessive 31
DGAT1 diacylglycerol O-acyltransferase 1
DGAT2 diacylglycerol O-acyltransferase 2
E2F1 E2F transcription factor 1
EDN2 endothelin 2
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELMO1 engulfment and cell motility 1
ELMOD1 ELMO/CED-12 domain containing 1
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
EPM2AIP1 EPM2A (laforin) interacting protein 1
ERCC1 excision repair cross-complementation group 1
ESR2 estrogen receptor 2 (ER beta)
FABP3 fatty acid binding protein 3, muscle and heart
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM134C family with sequence similarity 134, member C
FGF21 fibroblast growth factor 21
FGF23 fibroblast growth factor 23
FGFR2 fibroblast growth factor receptor 2
FOXA1 forkhead box A1
G6PC glucose-6-phosphatase, catalytic subunit
G6PC2 glucose-6-phosphatase, catalytic, 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCGR glucagon receptor
GCK glucokinase (hexokinase 4)
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GHR growth hormone receptor
GHRHR growth hormone releasing hormone receptor
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAS GNAS complex locus
GNMT glycine N-methyltransferase
GPC3 glypican 3
GPR68 G protein-coupled receptor 68
GSK3B glycogen synthase kinase 3 beta
GYS2 glycogen synthase 2 (liver)
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HADH hydroxyacyl-CoA dehydrogenase
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HELLS helicase, lymphoid-specific
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HLTF helicase-like transcription factor
HMGB1 high mobility group box 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IFT80 intraflagellar transport 80
IFT88 intraflagellar transport 88
IGF1 insulin-like growth factor 1 (somatomedin C)
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL10RB interleukin 10 receptor, beta
INHBA inhibin, beta A
INPP5K inositol polyphosphate-5-phosphatase K
INPPL1 inositol polyphosphate phosphatase-like 1
IRS1 insulin receptor substrate 1
IRS4 insulin receptor substrate 4
JAK1 Janus kinase 1
JAM3 junctional adhesion molecule 3
JUND jun D proto-oncogene
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KL klotho
KLF15 Kruppel-like factor 15
LCLAT1 lysocardiolipin acyltransferase 1
LDHA lactate dehydrogenase A
LEP leptin
LEPR leptin receptor
LMNA lamin A/C
LRP6 low density lipoprotein receptor-related protein 6
MAGEL2 melanoma antigen family L2
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MARK4 MAP/microtubule affinity-regulating kinase 4
MBD5 methyl-CpG binding domain protein 5
MBOAT4 membrane bound O-acyltransferase domain containing 4
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MECOM MDS1 and EVI1 complex locus
MEN1 multiple endocrine neoplasia I
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MIR184 microRNA 184
MIR378A microRNA 378a
MSTN myostatin
MYBBP1A MYB binding protein (P160) 1a
NACAD NAC alpha domain containing
NAMPT nicotinamide phosphoribosyltransferase
NCOA3 nuclear receptor coactivator 3
NFE2L2 nuclear factor, erythroid 2-like 2
NMNAT1 nicotinamide nucleotide adenylyltransferase 1
NMUR2 neuromedin U receptor 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NPC1L1 NPC1-like 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR2C2 nuclear receptor subfamily 2, group C, member 2
NSUN2 NOP2/Sun RNA methyltransferase family, member 2
ONECUT1 one cut homeobox 1
OXCT1 3-oxoacid CoA transferase 1
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6
PANK1 pantothenate kinase 1
PARVB parvin, beta
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK2 proprotein convertase subtilisin/kexin type 2
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDYN prodynorphin
PGR progesterone receptor
PHF20 PHD finger protein 20
PHIP pleckstrin homology domain interacting protein
PHOX2A paired-like homeobox 2a
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PITPNA phosphatidylinositol transfer protein, alpha
PNPLA2 patatin-like phospholipase domain containing 2
POLG polymerase (DNA directed), gamma
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1R3B protein phosphatase 1, regulatory subunit 3B
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PTF1A pancreas specific transcription factor, 1a
PTHLH parathyroid hormone-like hormone
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RETN resistin
RIMS2 regulating synaptic membrane exocytosis 2
RMI1 RecQ mediated genome instability 1
RNF183 ring finger protein 183
RNF213 ring finger protein 213
RPE65 retinal pigment epithelium-specific protein 65kDa
RRAGA Ras-related GTP binding A
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RUNX3 runt-related transcription factor 3
SAMD4A sterile alpha motif domain containing 4A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SEC23B Sec23 homolog B (S. cerevisiae)
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SERTAD2 SERTA domain containing 2
SIK3 SIK family kinase 3
SIRT6 sirtuin 6
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SMOC1 SPARC related modular calcium binding 1
SNRPN small nuclear ribonucleoprotein polypeptide N
SOCS7 suppressor of cytokine signaling 7
SOD2 superoxide dismutase 2, mitochondrial
SPNS2 spinster homolog 2 (Drosophila)
SPP1 secreted phosphoprotein 1
SPTB spectrin, beta, erythrocytic
SSFA2 sperm specific antigen 2
SSTR5 somatostatin receptor 5
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SUCO SUN domain containing ossification factor
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SYTL4 synaptotagmin-like 4
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D4 TBC1 domain family, member 4
TBKBP1 TBK1 binding protein 1
TBX19 T-box 19
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TNF tumor necrosis factor
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TRAF3 TNF receptor-associated factor 3
TRIP10 thyroid hormone receptor interactor 10
TWIST2 twist family bHLH transcription factor 2
TXNIP thioredoxin interacting protein
UBE3B ubiquitin protein ligase E3B
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
UMOD uromodulin
USH1C Usher syndrome 1C (autosomal recessive, severe)
VGF VGF nerve growth factor inducible
VIPR1 vasoactive intestinal peptide receptor 1
WWOX WW domain containing oxidoreductase
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZBTB20 zinc finger and BTB domain containing 20
ZMPSTE24 zinc metallopeptidase STE24