decreased circulating cholesterol level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005179
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Genes

166 gene mutations causing the decreased circulating cholesterol level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACOT11 acyl-CoA thioesterase 11
ACTB actin, beta
ADGRF5 adhesion G protein-coupled receptor F5
ADIPOR2 adiponectin receptor 2
ADORA2B adenosine A2b receptor
AEBP1 AE binding protein 1
AHCYL1 adenosylhomocysteinase-like 1
AKAP9 A kinase (PRKA) anchor protein 9
ANGPTL3 angiopoietin-like 3
ANGPTL4 angiopoietin-like 4
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOA4 apolipoprotein A-IV
APOB apolipoprotein B
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APOM apolipoprotein M
BAG3 BCL2-associated athanogene 3
BHMT betaine--homocysteine S-methyltransferase
BTK Bruton agammaglobulinemia tyrosine kinase
CAT catalase
CBX6 chromobox homolog 6
CDH23 cadherin-related 23
CES1 carboxylesterase 1
CHD7 chromodomain helicase DNA binding protein 7
CLPS colipase, pancreatic
CRHR2 corticotropin releasing hormone receptor 2
CXCL14 chemokine (C-X-C motif) ligand 14
CYP8B1 cytochrome P450, family 8, subfamily B, polypeptide 1
DBN1 drebrin 1
DHCR24 24-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIO1 deiodinase, iodothyronine, type I
DLG2 discs, large homolog 2 (Drosophila)
DLL1 delta-like 1 (Drosophila)
DUSP1 dual specificity phosphatase 1
ELMOD1 ELMO/CED-12 domain containing 1
ELOVL6 ELOVL fatty acid elongase 6
FABP2 fatty acid binding protein 2, intestinal
FABP6 fatty acid binding protein 6, ileal
FAM117B family with sequence similarity 117, member B
FAM134C family with sequence similarity 134, member C
FGL1 fibrinogen-like 1
FOXA1 forkhead box A1
FOXO1 forkhead box O1
G6PC3 glucose 6 phosphatase, catalytic, 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GHR growth hormone receptor
GHRHR growth hormone releasing hormone receptor
GNAS GNAS complex locus
GPAM glycerol-3-phosphate acyltransferase, mitochondrial
GPIHBP1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
GUSB glucuronidase, beta
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HNF4A hepatocyte nuclear factor 4, alpha
HPN hepsin
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IL10 interleukin 10
IL1RN interleukin 1 receptor antagonist
INPPL1 inositol polyphosphate phosphatase-like 1
IRS1 insulin receptor substrate 1
JAK1 Janus kinase 1
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3
KISS1R KISS1 receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLB klotho beta
KPNA1 karyopherin alpha 1 (importin alpha 5)
LCAT lecithin-cholesterol acyltransferase
LCH Lentil agglutinin-binding
LDLR low density lipoprotein receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
LPL lipoprotein lipase
MALRD1 MAM and LDL receptor class A domain containing 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK4 MAP/microtubule affinity-regulating kinase 4
MBTPS1 membrane-bound transcription factor peptidase, site 1
MCF2L MCF.2 cell line derived transforming sequence-like
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MIA2 melanoma inhibitory activity 2
MIER1 mesoderm induction early response 1, transcriptional regulator
MIR122 microRNA 122
MLXIPL MLX interacting protein-like
MOGAT2 monoacylglycerol O-acyltransferase 2
MSTN myostatin
MTA1 metastasis associated 1
MTTP microsomal triglyceride transfer protein
MYO6 myosin VI
MYO7A myosin VIIA
MYSM1 Myb-like, SWIRM and MPN domains 1
NCOA3 nuclear receptor coactivator 3
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
NPC1L1 NPC1-like 1
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR2C2 nuclear receptor subfamily 2, group C, member 2
NR5A2 nuclear receptor subfamily 5, group A, member 2
NSUN2 NOP2/Sun RNA methyltransferase family, member 2
OED Oregon eye disease
OSTM1 osteopetrosis associated transmembrane protein 1
P2RY13 purinergic receptor P2Y, G-protein coupled, 13
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PARVB parvin, beta
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PCSK9 proprotein convertase subtilisin/kexin type 9
PDE10A phosphodiesterase 10A
PEMT phosphatidylethanolamine N-methyltransferase
PEX2 peroxisomal biogenesis factor 2
PHYH phytanoyl-CoA 2-hydroxylase
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PITX3 paired-like homeodomain 3
PLA2G12B phospholipase A2, group XIIB
PLTP phospholipid transfer protein
PLVAP plasmalemma vesicle associated protein
PNLIP pancreatic lipase
PNPLA2 patatin-like phospholipase domain containing 2
PON2 paraoxonase 2
POR P450 (cytochrome) oxidoreductase
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCI protein kinase C, iota
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RNF10 ring finger protein 10
RORA RAR-related orphan receptor A
SAMD4A sterile alpha motif domain containing 4A
SAR1B secretion associated, Ras related GTPase 1B
SEC14L2 SEC14-like 2 (S. cerevisiae)
SEC16B SEC16 homolog B (S. cerevisiae)
SEC24A SEC24 family member A
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERTAD2 SERTA domain containing 2
SETD1A SET domain containing 1A
SIK3 SIK family kinase 3
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC51A solute carrier family 51, alpha subunit
SOAT2 sterol O-acyltransferase 2
SREBF1 sterol regulatory element binding transcription factor 1
STARD10 StAR-related lipid transfer (START) domain containing 10
STARD4 StAR-related lipid transfer (START) domain containing 4
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SYT1 synaptotagmin I
TBC1D10A TBC1 domain family, member 10A
TLR2 toll-like receptor 2
TMC6 transmembrane channel-like 6
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRPC3 transient receptor potential cation channel, subfamily C, member 3
UBE3B ubiquitin protein ligase E3B
UMOD uromodulin
USH1C Usher syndrome 1C (autosomal recessive, severe)
UTS2 urotensin 2
VANGL2 VANGL planar cell polarity protein 2
WWOX WW domain containing oxidoreductase
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble