decreased cellular sensitivity to ionizing radiation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description decreased incidence of cell death following exposure to ionizing radiation (Mammalian Phenotype Ontology, MP_0004228)
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26 gene mutations causing the decreased cellular sensitivity to ionizing radiation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ATM ATM serine/threonine kinase
BBC3 BCL2 binding component 3
CASP9 caspase 9, apoptosis-related cysteine peptidase
CHEK2 checkpoint kinase 2
CUL9 cullin 9
CYCS cytochrome c, somatic
DDB2 damage-specific DNA binding protein 2, 48kDa
GPX1 glutathione peroxidase 1
HELLS helicase, lymphoid-specific
HINT1 histidine triad nucleotide binding protein 1
HIST1H1C histone cluster 1, H1c
MAP2K6 mitogen-activated protein kinase kinase 6
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
NBN nibrin
NDRG1 N-myc downstream regulated 1
NIT1 nitrilase 1
PER2 period circadian clock 2
PERP PERP, TP53 apoptosis effector
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAD51D RAD51 paralog D
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TP53 tumor protein p53
TP63 tumor protein p63